原发性高血压患者血尿酸水平与心脏超声E／A值相关性的研究

The study of serum uric acid associating with the value of E/A of echocardigraphy in the patient with essential hypertension

目的探讨原发性高血压患者血尿酸水平与心脏超声脉冲多普勒二尖瓣口血流频谱E峰与A峰流速比值（E／A值）的相关性。方法选择46例确诊为原发性高血压的患者，利用生化仪测定血尿酸，心脏彩超测定E／A值。结果原发性高血压患者血尿酸水平与E／A值呈负相关，差异无统计学意义。男、女两组尿酸水平比较差异有统计学意义（P〈0．05），心脏超声E／A值比较差异无统计学意义（P〉0．05）。〈60岁和≥60岁两个年龄组尿酸水平差异无统计学意义（P〉0．05），心脏超声E／A值比较差异有统计学意义（P〈0．05）。汉族与少数民族两组尿酸水平差异无统计学意义（P〉0．05），心脏超声E／A值比较差异无统计学意义（P〉0．05）。结论原发性高血压患者随血尿酸浓度增高，心脏舒张功能减低。

Objective To investigate the relationship between serum uric acid and the value of E/A of echocardiography. Methods 46 patients with essential hypertension were enrolled, serum uric acid was measured with biochemistry instrument. The value of E/A was measured with echocardiography. Results Serum uric acid was negative associated with the value of E/A. Population statistical inference was no significance according to lev- el of a test： α=0.05 or α=0.1. Serum uric acid has significance in men group compared with women group （P〈 0.05 ）. The value of E/A of echocardiography was no significance in men group compared with women group （P〉 0.05 ）. In the group of age, the serum uric acid was no significance in the group of 〈60 years compared with the group of≥60 years （P〉0.05）. The value of E/A of echocardiography has significance in the group of 〈60 years compared with the group of ≥60 years （P〈0.05）. The serum uric acid was no significance in the group of Han nationality compared with the group of minority nationality （P〉0.05）. The value of E/A of echocardiography was no significance in the group of Han nationality compared with the group of minority nationality （P〉0.05）. Conclusion In the patients with essential hypertension, with the increasing of serum uric acid, the diastolic function of heart is decreasing.