雌激素受体α和β及表皮生长因子受体的表达与非小细胞肺癌临床病理特点关系

Expressions and clinicopathological characteristics of estrogen receptor α,β and epidermal growth factor receptor in non-small cell lung cancer

目的:研究雌激素受体(ER)α和β与表皮生长因子受体(EGFR)在非小细胞肺癌(NSCLC)患者的表达情况及其与临床病理特点的关系。方法:收集有组织学病理诊断的164例非小细胞肺癌患者的肺癌组织及其相关临床资料,免疫组化方法检测ERα和ERβ与EGFR的表达情况,分析其表达与临床病理特点的关系。结果:164例非小细胞肺癌患者中,ERα表达阳性率为8.5%(14/164),ERβ表达阳性率89.0%(146/164),表皮生长因子受体阳性率为57.9%(95/164)。ERα的阳性表达与NSCLC患者的年龄和疾病的分期有关,<60岁的年轻患者(14.1%,P=0.043)和I、Ⅱ期的患者(17.3%,P<0.001)的表达率更高;ERβ的表达在年轻患者(95.3%,P=0.039)和疾病分期较晚的患者(95.2%,P=0.011)中有更高阳性率表达,在肺腺癌(67.6%,P=0.032)和高分化肺癌(83.3%,P=0.001)的患者ERβ(++)-(+++)高表达率更高;EGFR阳性率在女性(69.8%,P=0.033)和不吸烟的患者(68.9%,P=0.01)更高。结论:ERα、β和EGFR在非小细胞肺癌患者的表达情况与患者的临床病理特点具有相关性,提示雌激素受体的表达可能与非小细胞肺癌的发生、发展有着密切关系,有可能成为非小细胞肺癌治疗的新靶点。

Objective：To evaluate the expressions of estrogen receptor（ER）a, [3 and epidermal growth factor re- ceptor（EGFR） in non -small cell lung cancer（NSCLC） patients and their relationship with clinical and pathological characters. Methods：Immunohistochemical assay was used to detect the expressions of ERa, B and EGFR in 164 NSCLC patients,and analyzed the correlations with the clinical and pathological characteristics. Results：The positive rates of ERoL,B and EGFR in 164 NSCLC were 8.5% （14/!64） ,89.0% （146/164） and 57.9% （95/164） ,respec- tively. There were correlations between the ERo expressions and the patient ages and tumor stages. The positive rates were higher in younger patients （ 〈 60 years, 14.1% ,P = 0. 043 ） and early stages （stage I and II , 17.3% ,P 〈 0. 001 ）. The positive rates of ER[3 were higher in younger patients （95.3 %, P = 0. 039） and advanced stage patients （95.2% ,P =0.011）. The ER[3 expressions were much stronger in adenocarcinoma（67.6% ,P =0. 032） ,and high degree differentiation cases（ 83.3% ,P = 0.001 ）. The expression rates of EGFR were higher in female （69.8%, P = 0.033） and non- smokers（68.9%, P= 0.01 ）i Conclusion： The expressions of ERot, and EGFR correlated with clinical and pathological characteristics of NSCLC patients. It indicated that the expressions of ERoL and Bmight play an imnortant role in the occurrence and develonment of NSCLC. and might be a new theranv target in NSCI.C.