干扰素聚乙二醇修饰的研究进展

Advances in research on PEGylation of interferon

干扰素(Interferon,IFN)是一类具有抗病毒、免疫调节、抑制细胞增殖等多种生物活性的细胞因子,而体内循环半衰期短限制了其在临床上的应用。聚乙二醇(Polyethylene glycol,PEG)修饰可以有效地改善干扰素的理化性质和生物学特性,延长体内循环半衰期。本文综述了聚乙二醇修饰干扰素的研究进展,着重介绍了聚乙二醇修饰化学的发展,α、β、γ干扰素各自不同的聚乙二醇化学修饰方法,并对聚乙二醇化干扰素的发展趋势进行了展望。

Interferon （IFN） contains a family of cytokines that display a wide range of antiviral, immunomodulatory, and antiproliferative activities, but unfortunately the short circulating half-life limits their clinical applications. PEGylation may improve the physicochemical and biological characteristics, and extend the plasma circulating half-life of IFN. Recent advances in PEGylation of IFNs were reviewed in this paper, while the development of PEGylation of IFNs α, β, and γwere particularly introduced. Finally, the future trends and prospects in PEGylation of IFNs were predicted.