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雄激素性秃发与相关基因的研究 被引量：3

Progress in causative genes of androgen alopecia
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摘要 雄激素性秃发(AGA)是临床上最为常见的脱发性疾病,分为男性型脱发和女性弥漫性脱发,不同人种发病率不同。近年来研究认为AGA是一种多基因遗传性疾病,雄激素和遗传因素在AGA发病中扮演了重要角色,多个基因与AGA关系密切。胰岛素抵抗被证明与AGA无关,而严重的心血管疾病则与AGA有关,具体机制还有待于进一步研究。
作者 符红阳 董瑛 杨春俊 张学军
机构地区 安徽医科大学皮肤病研究所第一附属医院皮肤性病科
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2013年第3期195-196,共2页 Journal of Clinical Dermatology
基金 国家自然科学基金(30771941) 中华医学会-法国欧莱雅基金资助项目
关键词 雄激素性秃发 病因 易感基因
分类号 R758.71 [医药卫生—皮肤病学与性病学]
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参考文献10

  • 1Xu F,Sheng YY, Mu ZL, et al. Prevalence and types of andro-genetic alopecia in Shanghai, China: a community-based study[J]. Br J Dermatol, 2009, 160(3): 629-632.
  • 2El-Domyati M, Attia S, Saleh F,et al. Evaluation of apoptosisregulatory markers in androgenetic alopecia[J]. J Cosmet Derma-tol, 2010,9(4): 267-275.
  • 3Prodi DA, Pirastu N, Maninchedda G, et al. EDA2R is associ-ated with androgenetic alopecia [J]. J Invest Dermatol, 2008,128(9): 2268-2270.
  • 4Zhuo FL, Xu W, Wang L,et al. Androgen receptor gene poly-morphisms and risk for androgenetic alopecia: a meta-analysis[J].Clin Exp Dermatol, 2012,37(2): 104-111.
  • 5Cobb JE, Zaloumis SG, Scurrah KJ, et al. Evidence for two in-dependent functional variants for androgenetic alopecia aroundthe androgen receptor gene [J]. Exp Dermatol, 2010, 19(11):1026-1028.
  • 6el-Samahy MH, Shaheen MA, Saddik DE, et al. Evaluation ofandrogen receptor gene as a candidate gene in female androge-netic alopecia[J]. Int J Dermatol,2009, 48(6): 584-587.
  • 7Redler S, Brockschmidt FF,Tazi-Ahnini R, et al. Investigationof the male pattern baldness major genetic susceptibility lociAR/EDA2R and 20pll in female pattern hair loss[J]. Br J Der-matol, 2012,166(6): 1314-1318.
  • 8Brockschmidt FF, Heilmann S, Ellis JA, et al. Susceptibilityvariants on chromosome 7p21.1 suggest HDAC9 as a new candi-date gene for male-pattern baldness [J]. Br J Dermatol,2011,165(6): 1293-1302.
  • 9Riedel-Baima B, Riedel A. Female pattern hair loss may betriggered by low oestrogen to androgen ratio [J]. Endocr Regul,2008’ 42(1): 13-16.
  • 10Magro CM, Rossi A, Poe J, et al. The role of inflammation andimmunity in the pathogenesis of androgenetic alopecia [J]. JDrugs Dermatol, 2011, 10(12): 1404-1411.

同被引文献37

  • 1Wang T L,Zhou C,Shen Y W. Prevalence of androgenetic alopecia in China:a community-based study in six cities[J].{H}British Journal of Dermatology,2010,(4):843-847.
  • 2Shapiro J. Hair loss in women[J].{H}New England Journal of Medicine,2007,(16):1620-1630.
  • 3Tosti A,Piraccini BM,Iorizzo M. Frontal fibrosing alopecia in postmenopausal women[J].{H}Journal of The American Academy of Dermatology,2005,(1):55-60.
  • 4Yip L,Rufaut N,Sinclair R. Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss:an update of what we now know[J].{H}Australasian Journal of Dermatology,2011,(2):81-88.
  • 5Hillmer AM,Hanneken S,Ritzmann S. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia[J].{H}American Journal of Hunan Genetics,2005,(1):140-148.
  • 6McElwee KJ,Shapiro JS. Promising therapies for treating and/or preventing androgenic alopecia[J].{H}Skin Therapy Letter,2012,(6):1-4.
  • 7Blumeyer A,Tosti A,Messenger A. Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men[J].{H}JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT,2011.S1-S57.
  • 8Alsantali A,Shapiro J. Androgens and hair loss[J].Curr Opin Endocrinol Diabetes Obes,2009,(3):246-253.
  • 9Olsen EA,Whiting D,Bergfeld W. A multicenter,randomized,placebo-controlled,double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men[J].{H}Journal of The American Academy of Dermatology,2007,(5):767-774.
  • 10Mella JM,Perret MC,Manzotti M. Efficacy and safety of finasteride therapy for androgenetic alopecia:a systematic review[J].{H}ARCHIVES OF DERMATOLOGY,2010,(10):1141-1150.

引证文献3

二级引证文献17

临床皮肤科杂志
2013年 第3期

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