抵克立得与藻酸双酯钠对COPD高凝状态作用的比较

The application of ticlid and PSS for hypercoagulability:a clinical comparison in COPD

目的 探讨慢性阻塞性肺疾病 (COPD)高凝状态时试用抵克立得与藻酸双酯钠的治疗效果比较。 方法 使用血液流变仪 ,血液凝集仪和肺功能仪对老年COPD高凝血症伴血小板聚集亢进患者 6 0例进行治疗前后血液流变学 ,血小板聚集率及肺功能 (包括肺弥散功能 )的检测。 结果 抵克立得组在降低全血粘度、红细胞压积、纤维蛋白原和血小板聚集方面较藻酸双酯钠组疗效更为明显 (P <0 0 0 1,0 0 1) ,而治疗前后肺功能 (包括肺弥散功能 ) 2组均无明显改变 (P >0 0 5 )。 结论 抵克立得与藻酸双酯钠均有降低血液粘度的作用 ,但前者作用更强一些。

Objective To investigate of therapeutic effect of ticlid and PSS for hypercoagulability of COPD. Methods We used blood rheometer manufactared by Beijing PRECIL group,coagulometer by Shanghai General Instrument Co.,and pulmameter (Spirolab model 3500) by American Spirometreics Inc.in testing blood rheology,platelet aggregation and lung function(including lung diffusion function) pre and post treatment for 60 old patients with COPD who had hypercoagulability and sthenic platelet aggregation. Results Ticlid group was more obviously effective than PSS in reducing blood viscosity,hematocrit,fibrinogen and platelet aggregation ( P <0 001,0 01),and the two groups did not present obvious changes pre and post treatment in lung function(including lung diffusion function)( P >0 05). Conclusions Both of ticlid and PSS have curative effects in reducing blood viscosity,but ticlid displayed more obvious effects.