玫瑰红景天提取物rosavin抗疲劳作用的实验研究

Anti-fatigue effects of rosavin extracted from Rhodiola rosea L.

目的:研究玫瑰红景天提取物rosavin对小鼠的抗疲劳作用。方法:实验分为对照组、rosavin低、中、高剂量组(60,180,360mg/kgmb)以及红景天苷阳性对照组(180mg/kgmb),对照组灌胃生理盐水,连续灌胃30d。分别测定小鼠力竭游泳时间,运动后肌乳酸、肝糖原、肌糖原和血清尿素氮含量。结果:与对照组比较,rosavin组的高、中、低剂量组均能延长小鼠力竭游泳时间(p<0.05),运动后肝糖原(p<0.05)、肌糖原含量高于对照组小鼠,肌乳酸浓度明显低于对照组(p<0.05)。与红景天苷阳性对照组比较,同等剂量下红景天苷抗疲劳效果略优于rosavin,rosavin高剂量组与红景天苷抗疲劳效果相当,两者差异没有显著性(p>0.05)。结论:rosavin有缓解体力疲劳的作用。

Objective=To study the anti-fatigue effects of rosavin extracted from Rhodiola rosea L. in mice. Methods：The mice were randomly divided into five groups including the control group administered with physLological saline, three rosavin groups administered with doses of 60,180,360mg/kg mb rosavin and salidroside group （180mg/kg mb） for 30 consecutive days, respectively. And the level of muscle lactate, liver and muscle glycogen, serum urea nitrogen and the exhaustive swimming time were determined after swimming test. Results： Compared with control group, different doses of rosavin significantly extended the swimming time （p〈0.05） and increased the contents of liver （p〈0.05）and muscle glycogen, while reducing that of lactate in muscle significantly （p〈0.05）. Salidroside was slightly better than rosavin in the anti-fatigue effects of the same dose. But there was no significant difference in rosavin and salidroside （p〉0.05）. Conclusion, rosavin had anti- fatigue effect on mice.