食品中3-氯-1,2-丙二醇脂肪酸酯研究进展

Research progress in the toxicity of 3-chloro-1,2-propanediol esters

3-氯-1,2-丙二醇(3-MCPD)作为一种公认的食品污染物已有数十年之久。随着对3-MCPD的深入研究,在越来越多的食品中检测出较高含量的3-MCPD。最近的研究发现3-MCPD更多地以酯化形式存在于咖啡、婴幼儿配方奶粉及食用油等很多食品中。这些存在于食品中的3-MCPD脂肪酸酯(3-MCPD酯)在一定条件下能够释放3-MCPD,从而引起对机体的毒性作用。目前已有研究报道了3-MCPD棕榈酸单酯在动物体内的急性毒性作用和细胞毒性作用,因此,进一步深入研究3-MCPD酯的毒性显得尤为重要。本文对3-MCPD酯在食品中的存在及影响因素、检测方法、代谢转化以及毒性研究进行了综述。

3- chloro- 1,2- propanediol （3- MCPD） has been known for decades as a food - processing contaminant. With further research,3-MCPD has been detected in more and more foods. Recent findings have documented that this food-borne contaminant occurs in foods either free or, even in much larger amounts, mostly esterifies with fatty acids. 3-MCPD fatty acid esters （3-MCPD esters） had been detected in many kinds of foods including coffee, infant formulas and oils. The hydrolysis of 3-MCPD esters may lead to the release of free 3-MCPD in a certain condition and thus the released 3-MCPD from esters may cause the body＇s toxic effect. The researcher has reported that the acute oral toxicity and the cytotoxicity of 3-MCPD monopalmitate. Therefore,the further research of 3-MCPD esters＇ toxicity is particularly important. The source of 3-MCPD esters in foods,the factors influencing their formation, recent technological advances for their determination, also, their metabolic transformation and toxicity research were reviewed in this paper.