期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肾交感神经对肾素血管紧张素醛固酮系统的影响 被引量：7

原文传递
导出
摘要 高血压是常见的心血管疾病之一，国外相关数据显示约31％的成人患有高血压，在年龄〉65岁的人群中高血压患病率达70％[1]。我国情况也不容乐观[2]。高血压患者中，难治性高血压占20％～359，6口]，通常药物疗效不佳。研究认为，肾交感神经和肾素血管紧张素醛固酮系统（renin—angiotensin-aldosteronesys—tem，RAAs）激活影响高血压的发生发展。
作者 陈炜 唐晓鸿
机构地区 中南大学湘雅三医院心内科
出处 《中华高血压杂志》 CAS CSCD 北大核心 2013年第2期127-129,共3页 Chinese Journal of Hypertension
基金 中南大学中央高校基本科研业务费专项基金资助(2012zzts121) 高等学校博士学科点专项科研基金资助课题(20120162120098) 湖南省科学技术厅科技计划重点项目基金资助(2012WK2002)
关键词 肾素血管紧张素醛固酮系统 肾交感神经 高血压患者 难治性高血压 心血管疾病 数据显示 疗效不佳 患病率
分类号 R544.1 [医药卫生—心血管疾病]
  • 相关文献

参考文献32

  • 1Yoon PW, Gillespie CD, George MG, et al. Control of hypertension among adults-national health and nutrition examination survey, United States, 2005 - 2008 [J]. MMWR Surveill Sumrn , 2012,61(2):19-25.
  • 2Li L, Guo Y, Chen Z, et al. Epidemiology and the control of disease in China, with emphasis on the Chinese biobank study[J]. Public Health,2012,126(3) :210-213.
  • 3Whitworth lA. 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension[J]. J Hypertens , 2003,21 (11) : 1983-1992.
  • 4Michaels S, Eppel GA, Burke SL, et al. Altered responsiveness of the kidney to activation of the renal nerves in fat-fed rabbits [J]. Am J Physiol Regul Integr Comp Physiol , 2009,296 (6): R1889-R1896.
  • 5Osborn JL, Dibona GF, Thames MD. Beta-I receptor mediation of renin secretion elicited by low-frequency renal nerve stimulation [J]. J Pharmacol Exp Ther, 1981.216(2): 265-269.
  • 6Reinhart GA, Lohmeier TE, Hord CJ. Hypertension induced by chronic renal adrenergic stimulation is angiotensin dependent[J], Hypertension, 1995,25(5) : 940-949.
  • 7Nakamura A, lohns EJ. Effect of renal nerves on expression of renin and angiotensinogen genes in rat kidneys[J]. Am J Physiol , 1994,266(2 Pt 1) :E230-E241.
  • 8Holmer SR, Kaissling B, Putnik K, et al. Beta-adrenergic stimulation of renin expression in vivo[J].J Hypertens,1997,15(12 Pt 1) :1471-1479.
  • 9Okuno T, Lindheimer MD, Oparil S. Central effects of prostaglandin E2 on blood pressure and plasma renin activity in rats. Role of the sympathoadrenal system and vasopressin [J]. Hypertension, 1982, 4(6) : 809-816.
  • 10Hisa H, Hayashi Y, Satoh S. Effects of blockades of alpha and beta adrenoceptors and dopamine receptors on renal nerve stimulation-induced prostaglandin E2 and renin release in anesthetized dogs[J].J Pharmacol Exp Ther,1985,235(2):481-486.

二级参考文献32

  • 1Zheng Z, Yenari MA. Post-ischemic inflammation: molecular mechanisms and therapeutic implications [J]. Neurol Res, 2004, 26 (8): 884-92.
  • 2Kwak HB, Sun HM, Ha H, et al. Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts[J]. Eur J Pharmacol, 2008, 601(1-3): 30-7.
  • 3Fu J, Huang H, Liu J, et al. Tanshinone HA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis [J]. Eur J Pharmacol, 2007, 568(1-3): 213-21.
  • 4Han JY, Fan JY, Horie Y, et al. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion [J]. Pharmacol Ther, 2008, 117(2): 280-95.
  • 5Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors [J]. Oncogene, 1999, 18(49): 6853-66.
  • 6Schwaninger M, Inta I,Herrmann O. NF-kappaB signalling in cerebral ischaemia[J]. Biochem Soc Trans, 2006, 34(Pt 6): 1291-4.
  • 7Valen G. Signal transduction through nuclear factor kappa B in ischemia-reperfusion and heart failure [J]. Basic Res Cardiol, 2004, 99(1): 1-7.
  • 8Auron PE. The interleuldn 1 receptor: ligand interactions and signal transduction [Jl. Cytokine Growth Factor Rev, 1998, 9 (3-4): 221-37.
  • 9Li X, Wang X. Application of real-time polymerase chain reaction for the quantitation of interleukin-lbeta mRNA upregulation in brain ischemic tolerance [J]. Brain Res Brain Res Protoc, 2000, 5 (2): 211-7.
  • 10Parry-Jones AR, Liimatainen T, Kauppinen RA, et al. Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat[J]. Magn Reson Med, 2008, 59(6): 1239-49.

共引文献18

同被引文献81

引证文献7

二级引证文献23

中华高血压杂志
2013年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部