microRNA与胃癌的研究进展

Research progress in microRNA and gastric carcinoma

目的:总结microRNA与胃癌的研究现状,探讨microRNA的生物合成、作用机制、检测方法及其在胃癌发生、发展过程中的作用。方法:采用PubMed期刊全文数据库检索系统,检索2000-01-2012-06以"microRNA、胃癌"为关键词的相关文献,共得到英文文献215条。以"microRNA的生物合成、作用机制、检测方法、胃癌发生与发展、耐药性"为纳入标准,符合条件的文献共有65篇。结果:microRNA是一种内源性非编码小RNA,能通过部分或完全与靶mRNA结合的方式调节靶mRNA的翻译,最终导致靶mRNA翻译受抑制甚至导致靶mRNA降解而失去生物活性,使相应基因表达受影响。结论:microRNA能通过转录后调控影响基因的表达,最终影响胃癌的发生、发展以及癌组织耐药性等。

OBJECTIVE： To summarize the research progress of microRNA and gastric cancer,and to investigate the biosynthesis procedure and the role in gastric cancer＇s happening/development of microRNA. METHODS： Based on Pubmed Journal Full text Database Retrieval Systems,literatures were searched with the key words of microRNA,Stom ach arcinoma from January 2000 to January 2012, and a total of 215 articles were obtained. Totally 65 papers were slected according to the criteria of biosynthesis,mechanism of action,detection,the role in gastric cancer＇s bappening/de- velopment of microRNA. RESULTS： MicroRNAs are little non coding RNA that regulate gene expression by partially or completely complementary binding to their target mRNAs, resulting in translational repression of these mRNAs,even mR- NA degradation,so the relevant gene expression is influenced. CONCLUSIONS： microRNAs can affect the expression of genes by post-transcriptional regulation,and then influence the happening and development of gastric cancer, drug resist anee and su on.