Ⅳ期乳腺癌局部区域治疗的研究进展

Progress of stage-Ⅳ breast cancer treated with local-regional therapy

目的:探讨Ⅳ期乳腺癌局部-区域治疗的方法、意义及对患者生存期的影响。方法:应用PubMed、CNKI及万方期刊全文数据库检索系统,以"乳腺肿瘤、Ⅳ期"和"局部治疗"或"区域治疗"等为关键词,检索2000-01-2012-10的相关文献。纳入标准:1)Ⅳ期乳腺癌局部-区域治疗的预后;2)Ⅳ期乳腺癌局部-区域治疗的措施及意义。根据纳入的标准,精选39篇文献进行分析。结果:Ⅳ期乳腺癌的局部-区域治疗可提高乳腺癌患者的中位生存时间;局部-区域治疗主要是通过手术或者局部放疗及两者联合的治疗方法来根治原发病灶,或减小肿瘤负荷、获得更详细的临床病理资料,同时局部治疗的介入也使综合治疗的顺应性更好,在一定程度上减轻患者的心理负担。结论:Ⅳ期乳腺癌在全身治疗的基础上,局部-区域治疗适时、适度的介入,是延长Ⅳ期乳腺癌患者的生存时间,改善患者的生活质量有效的治疗措施之一。

OBJECTIVE： To review the literature and evaluate the relation between local-regional therapy and the pa- tients survival rate in stage- breast cancer. METHODS： Using breast cancer, stage-.IV , local therapy and regional thera- py as keywords to retrieve 2000-01--2012-10 related papers on PubMed,CNKI and Wangfang database system. Criteri- on： 1） The prognosis of stage-iV breast cancer with local-regional therapy. 2） The measures and significance of stage- breast cancer with local-regional therapy. Thirty-nine literatures were selected to summarize. RESULTS： Large number of previous studies have demonstrated that local-therapy is a positive factor to improve survival in patients with stage-IV breast cancer. This treatment is mainly through the surgery or local radiotherapy to cure primary lesions and could can minimize the tumor load,get more clinical and pathological details. At the same time the intervention of local-regional ther- apy also makes comprehensive treatment adaptable and the psychological burden alleviatable for patients. CONCLUSION： It is a efficient measure to improve the patients＇ quality of life and to extend survival rate of stage- breast cancer when lo- cal-regional therapy appropriately applied on the basement of systemic threapy.