Wnt-1在病理性瘢痕中的表达及意义

Expression and significance of Wnt-1 in pathological scar

目的研究wnt-1在病理性瘢痕中的表达，探讨Wnt/β-catenin信号传导通路在病理性瘢痕发病机制中的作用。方法应用免疫组化技术检测Wnt-1在30例瘢痕疙瘩（A组）、30例增生性瘢痕（B组）及20例正常皮肤（C组）中的表达，并进行统计学分析。结果Wnt-1在A、B组中的表达与C组比较，其差异具有统计学意义（P〈0．05），但A、B组之间的差异无统计学意义（P〉0．05）。结论wnt．1可能是病理性瘢痕形成的重要机制，其导致的Wnt/β-catenin信号传导通路的激活在病理性瘢痕的形成机制中可能起着重要作用。

Objective To investigate the expression of Wnt-1 in pathological scar and to explore the role of Wnt/β-catenin signal transduction pathway in the pathogenesis of pathological scar. Methods Immunohis- tochemiscal techuique（IHC） was performed to detect the expression of Wnt-I in 30 cases of keloid （ group A）, 30 cases of hypertrophic scar （ group B） and 20 cases of normal skin （ group C）, and statistics was used to ana- lyze the data. Results Compared group A and group B with that in group C, there was significant difference in the expression of Wnt-1 （ P 〈 0.05 ）, but their expression was not statistically different between group A and B （ P 〉 0.05）. Conclusion Wnt-1 may be one of significant mechanisms in pathological scar formation. The activation ofWnt/β-catenin signal transduction pathway by Wnt-1 may play an important role in the formation of pathological scar.