摘要
上皮间质转化(EMT)是上皮细胞来源的恶性肿瘤细胞获得迁移和侵袭能力的重要生物学过程,在EMT的形成机制中,转化生长因子β(TGF-β)被认为起了关键性作用。笔者就EMT与肿瘤侵袭转移的关系,以及TGF-β介导EMT的相关信号通路进行综述。
Epithelial mesenchymal transition （EMT） is an important biological process enabling the malignant tumors of epithelial cell origin to acquire migratory and invasive ability. Among the mechanisms contributing to EMT, transforming growth factor β （TGF-β） is considered to play a key role. qhis paper overviews the relationship between EMT and tumor invasion and metastasis, and mentions the related signaling pathways mediated by TGF-β, which are responsible for EMT.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2013年第2期211-217,共7页
China Journal of General Surgery
关键词
肿瘤转移/病因学
上皮间质转化
转化生长因子Β
综述文献
Neoplasm Metastasis/etiol
Epithelial to Mesenchymal Transition
Transforming Growth Factor β
Review
