血尿酸水平与冠状动脉粥样硬化性心脏病的相关关系研究

Relationship between coronary heart disease and hyperuricemia

目的探讨血尿酸水平与冠状动脉粥样硬化性心脏病（冠心病）的关系及临床意义。方法选择经冠状动脉造影确诊的冠心病患者65例与35例非冠心病患者，并将冠心病组按冠脉狭窄范围分为单支病变组，双支病变组及三支病变组，分别测定血尿酸（SUA）水平，同时记录性别、年龄、血糖、血脂及冠状动脉造影结果。结果与对照组比较，冠心病组患者血尿酸水平明显高于对照组（P〈0．05），冠心病组中单只病组、双支病变组及多支病变组血尿酸水平呈递增趋势，各组之间的差异有统计学意义。结论冠心病与血尿酸水平密切相关。

Objective To study the relationship between coronary heart disease （CHD）. Methods Total 95 patients with CHD confined by angiography and subject without CHD were included in this study. The CHD group was divided into three subgroups single vessel disease, two vessels disease, and three vessels disease according to the scope of pathological changes. Serum uric acid and blood lipid were determined. The relative factors of CHD： gender, age, serum uric acid, diabetes, serum lipid were in- eluded . Results The serum uric acid level in CHD was higher than that in the non - CHD group （P 〈 0.05）. There was a trend of increase of SUA level in the single vessel disease, two vessels disease, and three vessels disease subgroup. There was significant difference between the these groups （P 〈 0.05 ）. Conclusions The serum uric acid level is associated with occurrence and development of CHD.