妊娠早期人巨细胞病毒感染与妇女自然流产的关系探讨

Study on the Relationship between Human Cytomegalovirus Infection in Early Pregnancy and Natural Abortion

目的 :探讨妊娠早期人巨细胞病毒(HCMV)感染和妇女自然流产的关系。方法 :采用ELISA和PCR分别对40例自然流产妇女和40例人工流产妇女和血清中人巨细胞病毒IgM抗体(HCMV—IgM)胎盘组织中人巨细胞病毒核酸(HCMV—DNA)进行检测。结果 :自然流产组妇女HCMV—IgM检出率为55 %(22/40) ,人工流产组妇女为25 %(10/40) ,自然流产组妇女胎盘组织HCMV—DNA检出率为10 %(4/10) ,而人工流产组为25 %(10/40) ;结论 :HCMV感染可能是早孕期间妇女自然流产的原因之一。

Objective: To explore the possible role of Human Cytomegalovirus (HCMV) as an etiological factor in miscarriage. Methods: HCMV-DNA in the placental tissues and HCMV-IgM in the sera were detected in 40 cases of natural abortion and 40 cases of artificial abortion by PCR and ELISA, separately. Results: The positive rates of HCMV-IgM and HCMV-DNA were 55% (22/40) and 10% (10/40) in the natural abortion group, 25% (10/40) and 2.5% (4/40) in the artificial abortion group. Conclusion: The results suggest that HCMV may play an indirect role in women with abortion in early pregnancy.