男性乳腺癌的综合治疗

The comprehensive treatment for male breast cancer

男性乳腺癌是一种少见的疾病,其发病率呈上升趋势。由于难以开展大宗的临床研究,男性乳腺癌的治疗基本参照女性乳腺癌的研究数据。外科手术以全乳切除加腋窝淋巴结清扫或前哨淋巴结活检为主。多数男性乳腺癌激素受体为阳性,因此,应用他莫昔芬是标准辅助治疗方法。辅助放射治疗和化疗的适应证参照女性乳腺癌标准。内分泌治疗是转移性男性乳腺癌的主要治疗方法,化疗和抗人类表皮生长因子受体2(HER2)治疗对部分病人有较好疗效。

Male breast cancer is a rare disease with a rise in the incidence. Treatment strategies for male breast cancer are derived from studies performed among females rather than randomized clinical studies. Surgery is usually mastectomy with axillary clearance or sentinel node biopsy. Tamoxifen is standard adjuvant therapy as most are strongly ER positive. Indications for adjuvant radiotherapy and chemotherapy are similar to female breast cancer although more evidence is needed for appropriate regimens. The treatment of metastatic disease is mainly hormonal, but chemotherapy and anti-HER2 therapy can also provide palliation.