负载有机膦的合成及其在有机催化领域的应用

Synthesis and Organocatalysis of Supported Phosphine

有机膦是一类重要的有机催化剂,作为一种亲核催化剂已得到广泛的应用。小分子叔膦作为一种均相催化剂影响产物的分离和催化剂的回收,将膦负载可以弥补上述缺陷。负载叔膦作为一类有机催化剂在近几年才受到关注。本文简要介绍了不同载体负载叔膦的合成方法及应用,综述了其催化Baylis-Hillman、加成、炔酮异构化和羟基保护反应的研究进展,并对研究前景进行了展望。

Phosphines are widely used in organic chemistry as nucleophilic catalysts. The employed phosphines are generally homogeneous, which make the separation of products and recovery of catalysts difficult. To overcome these limitations, heterogeneous supported phosphines as organocatalysts have gradually appeared and have been successfully applied in Baylis-Hillman faction, nucleophilic addition reaction, isomerization of ynones, and hydroxyl protection rection. In this article, the progress on synthesis and organocatalysis of supported phosphine with different grafts is reviewed. The outlook of the research area is provided.