Ⅱ型糖尿病和高血压患者血液动力学改变的相关因素分析

CORRELATION FACTOR ANALYSIS OF HEMODYNAMIC CHANGE IN PATIENTS WITH DIABETES ⅡAND HYPERTANSION

目的 :探讨糖尿病和高血压血管并发症的发生机理。方法 :分别测定高血压 (HT)组、Ⅱ型糖尿病 (NID DM)组及Ⅱ型糖尿病合并高血压组和对照组的胰岛素水平、血脂、心脏彩超和血液流变学指标。结果 :3个试验组的周围总阻 (TPR)、甘油三脂 (TG)和胰岛素面积 (InsS)均明显增高 ,其中HT组和NIDDM合并HT组的左室收缩期峰值室壁应力 (PSS)也明显增高 ;NIDDM合并HT组InsS明显高于其他三组 ;三试验组的PSS、TPR、TG与各自InsS分别呈正相关 ;3个试验组的全血粘度 (ηb)值明显增高 ,且TPR与全血高切粘度(ηbH)、全血低切粘度 (ηbL)呈显著正相关。结论 :高血脂、高血粘度。

Objective: To discuss the mechenism of the vascular complication of diabetes and hypertension. Methods: Divide patients into four group: hypertension (HT), diabetes II (NIDDM), diabetes II company with hypertension (NIDDM-HT) and control group, then determine the level of serum insulin, serum lipid, doppler echocardiography and hemodynamics. Results: Total perivascular resistance (TPR), triglyceride (TG), insuline surface (InsS) all increased in the three test groups, in which the PSS of left-ventricle of HT and NIDDM-HT groups, increased obviously, too. In NIDDM-HT group, InsS is obviously higher than other groups. In three test groups, PSS, TPR, TG have positive correlation with correspondently InsS. The value of ηb increased obviously in three test groups andηbh andηbl have posititive correlation with TPR. Conclusions: Hyperlipidemia, hyperviscosity, ηb and hyperinsulinemia are important factors of hemodynamics change in hypertension and diabetes II.