急性脑挫伤患者脑脊液神经元特异性烯醇化酶的变化及意义

NEURON-SPECIFIC ENOLASE LEVELS IN THE CEREBROSPINAL FLUID OF ACUTE BRAIN CONTUSION PATIENTS

目的 :探讨急性脑挫伤患者脑脊液中神经元特异性烯醇化酶 (Neuron -specificenolase,NSE)的变化。方法 :用放射免疫双抗体夹心法对 2 4例广泛脑组织挫伤组 ,30例局部脑挫伤及正常对照组脑脊液NSE含量进行测定。并测定各组冬氨酸转氨酶 (Aspartatetranscarbamoylsse ,AST)水平。结果 :弥漫性脑挫伤患者脑脊液NSE浓度为 (2 5 .43± 5 .6 1)ng/ml,局灶性脑挫伤组为 (14.6 1± 7.5 2 )ng/ml,对照组为 (7.81± 3.2 1)ng/ml,脑挫伤组明显高于对照组 (P <0 .0 5 ) ,且弥漫性脑挫伤组与局灶性脑挫伤组差异显著 (P <0 .0 5 )。脑挫伤组中AST明显高于对照组 ,但AST在广泛脑挫伤组与局部脑挫伤组中无明显差异。结论 :急性脑挫伤患者的NSE、AST水平升高 ,且NSE与脑挫伤体积相关 。

Objective: To observe the variations of neuron-specific enolase (NSE) in the CSF of acute brain contusion patients. Methods: NSE, AST were measured in widespread brain contusion group (group 1), part brain contusion group (group 2) and control group (group 3). Results: NSE in CSF of group 1 was 25.43±5.61ng/ml, group 2 was 14.61±7.52ng/ml and group 3 was 7.81±3.21ng/ml. The contusion groups were significantly higher than control group (p<0.05). Significant difference was observed between group 1 and group 2. Conclusions: NSE levels rise in CSF of acute brain contusion patients, and the levels direct relative with the volume of contusion. NSE may be a reliance index in judging the degree of brain contusion and prognosis.