头孢吡肟的临床应用与评价

Clinical Application and Evaluation of Cefepime

目的:评价徐州医学院附属医院部分科室住院患者头孢吡肟的使用情况,为规范临床合理使用抗菌药物提供参考。方法:将医院2011年7月—2011年12月间使用头孢吡肟的住院患者2113份的病历,并随机抽取其中100份,采用回顾性药物利用评价(DUE)方法,收集、整理患者病历信息,包括使用头孢吡肟的理由、治疗过程、ADR和治疗效果,分析其临床使用的合理性。结果:100份患者病历中,符合头孢吡肟适应证的43例,使用前经细菌培养和药敏试验的分别为20例和11例,导致ADR为10例,临床症状具有明显改善的95例。结论:临床对细菌培养和药敏试验重视程度不够,送检率偏低,检验时间过长,不足以指导临床用药;对更换或联合使用抗菌药物无实验室依据或临床指征的仍需加强监管或用药的干预。

Objective： To evaluate the application ofcefepime in the inpatients in part of departments in Hospital Affiliated to Xuzhou Medical College and to provide reference for reasonable use of antibiotics. Methods： Among 2 113 records from July 2011 to Dec. 2011, 100 records of cefepime were randomly sampled. Medical information was collected and classified including the reason of cefepime utilization, treatment procedure, adverse drug reaction and curative effect, Drug utilization evaluation （DUE） method was used to analyze the rationality of drug use retrospectively. Results： Among 100 records, 43 cases were in line with cefepime indications, 20 cases and 11 cases were respectively underway bacterial culture and susceptibility testing before drug use, and 10 cases had adverse drug reaction： Clinical symptoms of 95 cases were obviously improved. Conclusions： Clinicians ignored bacterial culture and susceptibility testing, low pathogenic submission and testing for a long time which can not instruct the clinical treatmented sufficiently. Changing or joint use of antibiotics had to be supervised and intervented,when no laboratory evidence or clinical indications were found.