郴州地区3380株金葡菌感染的临床分布及耐药性分析

Distribution and Analysis of Drug Sensitivity of 3380 Strains of Staphylococcus Aureus in Chenzhou District

目的:分析郴州地区二级以上综合性医院金黄色葡萄球菌感染的临床分布与耐药情况,为临床控制金黄色葡萄球菌感染提供参考。方法:收集各医院细菌室临床感染患者标本,按《全国临床检验操作规程》要求分离、鉴定细菌以及按美国临床和实验室标准化研究所(CLSI)更新的标准判别药敏结果。结果:标本中分离出3380株金黄色葡萄球菌中,其中耐甲氧西林金黄色葡萄球菌(MRSA)2031株,甲氧西林敏感金黄色葡萄球菌(MSSA)1349株;其耐药率青霉素为92.51%,大环内酯类药物>70%,利福霉素和氯霉素<30%,未检出耐万古霉素和中介菌株;MRSA耐药率高于MSSA,且呈现多重耐药状态。结论:郴州地区MRSA感染率高,其耐药性严重,应加强细菌学培养与药敏试验,合理选用药物,延缓耐药菌的产生。

Objective： To analyse the drug sensitivity of 3 380 strains of Staphylococcus aureus in above level Ⅱ hospital in Chenzhou hospitals, and to provide the reference for the clinical control of Staphylococcus aureus infection. Methods： Nosocomial bacterial clinical infection patient specimens were collected, the drug sensitivity results of which was discriminated by the updated standards of clinical and Laboratory Standards Institute. Separation. Identification of bacteria was according to the requirement of ＂the national clinical laboratory standards＂. Results： 3 380 strains of Staphylococcus aureus were separated from all the specimens, 2 031 of which were methicillin resistant Staphylococcus aureus（MRSA）, and 1 349 of which was methicillin sensitive Staphylococcus aureus（MSSA）. Drug resistance rates to penicillin, macrolides, rifamycin and chloramphenicol are shown to be 92,51%, 〉 70% and 〈 30%, and no vancomytin-resistant, and intermediary strains were detected to separation of bacteria. Multiple drug resistance were shown to MRSA, and the drug resistance rate of which was higher than that of MSSA. Conclusion： This study suggests that should be strengthened the bacteriology and drug sensitivity tests and the rational use of drug should be performed to delay the produce of drug-resistant bacteria, because of the high-infection rate and serious resistance of Methicillin resistant Staphylococcus aureus, in Chenzhou Distrit.