犬左心房心肌细胞动作电位的计算机建模仿真研究

The Ionic Model of the Canine Left Atrial Action Potential

目的构建犬左心房心肌细胞动作电位的计算机仿真模型。方法在Ramirez-Nattel-Courtemanche心房肌细胞模型的基础上,根据离子流数据构建左心房心肌细胞的计算机仿真模型。结果计算机仿真的电流与实验得到的离子流相似,最后得到的动作电位与我们在单个左心房肌细胞记录到的动作电位基本一致。结论我们根据犬左心房肌细胞离子流数据构建的细胞模型较现有模型更符合左心房细胞的特性,为进一步仿真研究心房颤动的机制打下了良好的基础。

Objective To develop a mathematical model of the left atrial action potential （AP） using experimental data. Methods Using specific formulations of ionic currents, we developed a mathematical model of the left atrial AE Result The simulated ionic currents in a fashion similar to experimental recordings. The simulated AP resembles AP recorded from canine left atrial myocytes. Conclusion This revised model faithfully reproduced properties of the canine left AP, which would be a useful tool for studying the mechanisms of atrial fibrillation.