氧化应激在动脉粥样硬化中的作用

Roles of oxidative stress in atherosderosis

在病理条件下，机体内促氧化应激酶激活、线粒体呼吸链异常、氧自由基清除能力下降，导致氧自由基和促氧化因子生成增多。上述有害物质累积引起动脉管壁和血液成分发生相应的改变，如内皮依赖性舒张功能减退、炎性细胞因子激活、内皮结构破坏、血管平滑肌细胞增殖以及泡沫细胞形成等，从而在动脉粥样硬化的发生和发展过程中发挥着关键作用。目前，针对抗氧化治疗在心脑血管事件预防中的作用存在争议，有待进一步研究。

Under pathological conditions, promoting oxidative stress kinase to be activated in the body, mitochondrial respiratory chain abnormalities, and decreased oxygen flee radical scavenging capacity lead to increased oxygen free radicals and pro-oxidant factors. The accumulation of the above harmful substances lead to the corresponding changes of arterial wall and blood components, such as endothelium-dependent relaxation dysftmction, inflammatory cytokine activation, endothelial structural damage, vascular smooth muscle cell proliferation, and foam cell formation, thus play key roles in the processes of the occurrence and development of atherosclerosis. The role of antioxidant therapy in the prevention of cardio-cerebrovascular events remains controversial and needs to be further studied.