期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

白藜芦醇对细胞色素P450酶活性影响的研究进展 被引量：5

Advance of studies on effect of resveratrol on activity of cytochrome P450
原文传递
导出
摘要 白藜芦醇是一种天然的抗氧化剂,具有抗肿瘤、抗炎、缓解和预防心血管疾病等作用,研究白藜芦醇对常见细胞色素P450酶活性的影响,对临床白藜芦醇与其他药物联合使用具有积极意义。目前国内外大量的体内、体外实验证实白藜芦醇对细胞色素酶P450几种亚型的活性有影响,该文就近年的相关研究进行综述。 Resveratrol is a natural antioxidant, with such effects of anti-tumor, anti-inflammation, and relief and prevention of cardiovascular disease. Studies on the effect of resveratrol on the activity of eytochrome P450 are of positive significance to combined elinical administration of resveratrol and other drugs. As there are many in vivo and in vitro experiments proving the effect of resveratrol on the activity of cytochrome P450 at present, the essay summarizes relevant studies in recent years.
作者 陆瑶 黄志军 袁洪
机构地区 中南大学湘雅三医院 中南大学药学院
出处 《中国中药杂志》 CAS CSCD 北大核心 2013年第5期653-656,共4页 China Journal of Chinese Materia Medica
基金 国家"重大新药创制"科技重大专项(2012ZX0930301-4001) 重大基础研究前期研究专项(2011CB512001)
关键词 白藜芦醇 细胞色素酶 P450 resveratrol cytochrome P450
分类号 R285 [医药卫生—中药学]
  • 相关文献

参考文献30

  • 1Brisdelli F, D'Andrea Gabriele, Bozzi A. Resveratrol: a natural polyphenol with multiple chemopreventive properties [ J ] . Curt Drug Metab, 2009,10(6) :530.
  • 2Xu Q, Si L Y. Resveratrol role in cardiovascular and metabolic health and potential mechanisms of action [ J ]. Nutr Res,2012,32 (9) :648.
  • 3Chu L M, Lassaletta A D, Robich M P, et al. Resveratrol in the prevention and treatment of coronary artery disease[ J]. Curt Ath- eroscler Rep,2011,13 (6) :439.
  • 4Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, et al. Inhibi- tion and induction of human cytochrome P450 enzymes: current status[ J]. Arch Toxicol,2008, 82 (10) : 667.
  • 5Ulrich M Zanger, Miia Turpeinen, Kathrin Klein. Functional phar- macogeneties/genomies of human eytochromes P450 involved in drug biotransformation[J]. Anal Bioanal Chem,2008, 369(6):1093.
  • 6Vastano B C, Chen Y, Zhu N, et al. Isolation and identificationof stilbenes in two varieties of polygonum cuspidatum[ J]. J Agric Food Chem ,2000,48(2) :253.
  • 7Joseph A B, David A S. Therapeutic potential of resveratrol : the in vivo evidence [ J ]. Nature Review, 2006,6 ( 5 ) :493.
  • 8Wu J M, Hsieh T C. Resveratrol: a cardioprotective substance [J]. Ann NYAcadSci,2011,1215:16.
  • 9Guengerich F P. Reactions and significance of cytochrome P-450 enzymes[ J]. J Biol Chem, 1991,266(16) : 10019.
  • 10郭海方,邹晓丽,许卉,刘珂.丹参酚酸A对大鼠肝微粒体细胞色素P450酶系的影响[J].中国中药杂志,2010,35(3):348-351. 被引量：20

二级参考文献15

  • 1Venkatakrishnan K, Von M L, Greenblatt D J. Human drug metabolism and the cytochromes P450: Application and relevance of in vitro models [J]. J Clin Pharmacol, 2001,41 (11) : 1149.
  • 2Guengerich F P. Cytochrome P450s and other enzymes in drug metabolism and toxicity [ J ] AAPS J, 2006, 8 ( 1 ) : E101.
  • 3Qiu Furong, Zhang Rong, Sun Jianguo, et al. Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes [ J ]. Drug Metab Dispos, 2008,36(7) : 1308.
  • 4Bradford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding[ J ]. Anal Biochem, 1976,72:248.
  • 5黎莲娘,徐理纳,张均田,等.中药丹参的新水溶性活性成分--丹酚酸类化合物[J].中国医学科学院学报,1995,17(6):480.
  • 6徐叔云 卞如濂 陈修.药理实验方法学[M].北京:人民卫生出版社,2001.703-710.
  • 7PROKOP J, ABRMAN P, SELIGSON A L, et al. Resveratrol and its glycon piceid are stable polyphenols[J]. Med Food, 2006, 9(1): 11-14.
  • 8VITAGLIONE P, MORISCO F, CAPORASO N, et al. Dietary antioxidant compounds and liver health[J]. Crit Rev Food Sci Nutr, 2004, 44(8): 575-586.
  • 9PIVER B, BERTHOU F, DREANO Y, et al. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages[J]. Life Sci, 2003, 3(9): 1199-1213.
  • 10PIVER B, FER M, VITRAC X, et al. Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes[J]. Biochem Pharmacol, 2004, 68(4): 773-782.

共引文献47

同被引文献67

  • 1张燕婉,孟宪敏,王来元.浅谈高效液相色谱分析中常见问题及对策[J].中国医学装备,2006,3(7):51-54. 被引量：6
  • 2Wang B,Sun J,Li X,et al.Resveratrol pre-vents suppression of regulatory T—cellproduction,oxidative stress,and inflammation ofmice prone or resistant to high-fat diet-inducedobesity!J]. Nutrition Research,2013,33( 11).: 971 -981 .
  • 3Beauvieux MC,Stephant A,Gin H,et al.Resv-eratrol mainly stimulates the glycolytic ATPsynthesis flux and not the mitochondrialone[J]. Pharmacological Research, 2013(78).:11-17.
  • 4Mazzone G,Malaj N,Russo N,et al.Densityfunctional study of the antioxidant activity ofsome recently synthesized resveratrol analogues! J].Food Chem, 2013,141(3). : 2017-2024.
  • 5Timperio AM,D1 Alessandro A,Fagioni M,etal.Production of the phytoalexins trans-resveratrol and delta-viniferin in twoeconomy-relevant grape cultivars upon infectionwith Botrytis cinerea in field conditions[J].Plant Physiol Biochem, 2012,50( 1). : 65-71.
  • 6Rotches—Ribalta M, Andres—Lacueva C, EstruchR,et al.Pharmacokinetics of resveratrol metabolicprofile in healthy humans after moderateconsumption of red wine and grape extracttabletsfJ].Pharmacological Res,2012,66(5).:375-382.
  • 7Tome-Carneiro J,Larrosa M,Yanez-GasconMJ,et al.One-year supplementation with agrape extract containing resveratrol modulatesinflammatory—related microRNAs and cytokinesexpression in peripheral blood mononuclear cellsof type 2 diabetes and hypertensive patientswith coronary artery disease[J]. PharmacologicalRes,2013(72).:69-82.
  • 8Kong QJ,Ren XY,Hu N,et al.Identification ofisomers of resveratrol dimer and their analoguesfrom wine grapes by HPLC/MSn and HPLC/DAD—UV[J].Food Chemistry,2011,127(2).:727-734.
  • 9Bertelli A A E, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratro| [ J ]. Drugs Exp Clin Res,1996, 22(1) :61.
  • 10Ferrero M E, Bertelli A A, Pellegatta F, et al. Phytoalexin resveratrol ( 3-4'-5-trihydroxystilbene ) modulates granulocyte and monocyte endothelial adhesion [ J ]. Transplant Proc, 1998, 30 ( 8 ) :4191.

引证文献5

二级引证文献14

中国中药杂志
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部