卡前列素氨丁三醇注射液预防前置胎盘剖宫产产后出血临床观察

Clinical observation of carboprost tromethamine injection in prevention of postpartum bleeding in placenta previa

目的:探讨卡前列素氨丁三醇注射液(欣母沛)在预防前置胎盘剖宫产产后出血中的防治效果。方法:选择合并前置胎盘孕妇60例,随机分为对照组(胎儿娩出后宫体肌层注射缩宫素)、试验组(胎儿娩出后常规宫体肌层注射缩宫素,同时宫体肌层注射欣母沛),比较两者术中、术后2 h及术后24 h的出血量以及血红蛋白下降的变化。结果:试验组术中、术后2 h、24 h出血量分别为(219.90±26.39),(309.10±28.18),(323.67±22.13)mL,对照组分别为(367.60±35.86),(433.63±55.52),(428.37±55.87)mL,试验组出血量均少于对照组,P<0.05,差异有统计学意义。试验组血红蛋白下降为(1.04±0.27)mL,对照组(1.46±0.39)mL,试验组血红蛋白下降少于对照组,P<0.05,差异有统计学意义。结论:前置胎盘剖宫产术中预防性使用欣母沛,可明显减少术中和术后出血量,降低产后出血的发生率。

Objective： To explore the prevention and treatment effect of carboprost tromethamine injection for postpartum hemorrhage in placenta previa. Methods： Sixty cases of pregnant women with placenta previa were randomly divided into control group （harem body myometrial injection of oxytocin after delivery） and experiment group （ conventional palace myometrial injection of oxytocin combined with palace myometrial injection of carboprost tromethamine injection）. Blood loss volumes and hemoglobin changes during the operation and 2 hours and 24 hours after operation were compared. Results： The blood loss volumes during the operation and 2 hours and 24 hours after operation of the patients in the experiment group were （219.90± 26. 39）, （309. 10 ± 28. 18 ） and （323.67±22.13） mL, respectively,while those of the control group were （36.60±35.86）, （433.63 ±55.52） and （428.37± 55.87） mL, respectively. The blood loss volumes in the experiment group were significantly smaller than the control group （P 〈 0.05）. The hemoglobin decrease of the experiment group （ 1.04 ± 0.27） mL was significantly les than the control group （ 1.46 ± 0.39） mL （P 〈 0.05）. Conclusion ： Prophylactic use of carboprost tromethamine injection during cesarean section in patients with placenta previa can significantly reduce intraoperative and postoperative bleeding and the incidence of postpartum hemorrhage.