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Oct4在肿瘤发生发展中的作用 被引量：3

Role of oct4 in the tumorigenesis and development
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摘要 八聚体4(octamer 4,oct4)基因是POU转录因子家族中的一员,主要表达于胚胎干细胞、生殖干细胞及多种肿瘤细胞中,对维持胚胎干细胞的多潜能性和自我更新具有重要的作用,有望成为靶向治疗的新靶点。 Oct4 （octamer 4） gene is a member of the POU transcription factor family and predominantly expressed in embryonic stem cells, germline stem cells and tumor cells. It plays an important role in the maintenance of embryonic stem cell pluripotency and self-renewal. It is expected to become a new target for targeting therapy.
作者 黄灵 郜峰 张声
机构地区 福建医科大学第一临床医学院病理科
出处 《国际病理科学与临床杂志》 CAS 2013年第1期78-81,共4页 Journal of International Pathology and Clinical Medicine
基金 福建医科大学第一临床学院学科带头人培养对象专项基金(JXK200724)~~
关键词 oct4基因 肿瘤 多潜能性 oct4 gene tumor pluripotency
分类号 R730.2 [医药卫生—肿瘤]
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参考文献2

二级参考文献68

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  • 4Chang CC, Shieh GS, Wu P, et al. Oct-3/4 expression reflects tumor progression and regulates motility of bladder eancer cells [J]. Cancer Res, 2008,68(15):6281-6291.
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共引文献43

同被引文献24

  • 1王利,魏品康,秦志丰,徐永平,楼丽广,李玉莉,何金.葛根素注射液逆转人胃癌裸鼠原位移植瘤多药耐药性的实验研究[J].成都中医药大学学报,2005,28(1):42-44. 被引量：5
  • 2谢勇,王建宾.参麦注射液对白血病细胞多药抗药性逆转作用的实验研究[J].大同医学专科学校学报,2005,25(2):3-5. 被引量：14
  • 3陈立武,林晶,陈文,张伟平.中药治疗原发性肝癌Ⅲ期围手术期患者42例[J].中国中西医结合杂志,2005,25(9):832-834. 被引量：51
  • 4Chiba T, Kita K, ZhengYW, et al. Side Population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties [J]. Hepatology, 2006, 44 (1) :240-251.
  • 5Hu L, McArthur C, Jaffe RB. Ovarian cancer stem-like side-population cells are tumorigenic and chemoresistant [J]. Br J cancer, 2010, 102(8): 1276-1283.
  • 6Huan S, Pazdur R, Singhakowinta A, et al. Low-dose continuous infusion 5-fluorouracil evaluation in advanced breast carcinoma [J]. Cancer, 1989, 63(3):419-422.
  • 7Zhou S, Schuetz JD, Bunting KD, et al. The ABC transproter Bcrpl/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side- population phenotype [J]. Nat Med, 2001, 7(9): 1028-1034.
  • 8贾茜.肝癌干细胞筛选及Oct4、ABCG2对其耐药性影响的初步研究[D].重庆医科大学,2012.
  • 9张永杰,秦叔逵,王杰军,等.肠型胃癌中HDAC1与Oct4表达的相关性研究[J].中华临床医师杂志(电子版),2013,7(14):6387-6390.
  • 10Lee KS,Lee YS,Lee JM,et al.Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer[J].Oncogene,2010,29(23):3349-3361.

引证文献3

二级引证文献16

国际病理科学与临床杂志
2013年 第1期

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