丹红注射液对心肌梗死大鼠心功能和左室重构的改善作用

The improvement effect of Danhong injection on the cardiac function and left ventricular remodeling in myocardial infarction rats

目的:探讨丹红注射液(DHI)对心肌梗死大鼠的心功能和左室重构的改善作用。方法:采用冠状动脉结扎法(CAL)制备心肌梗死(MI)模型,观察DHI对大鼠心肌梗死后12周的心脏及肺的解剖学指标、心室的疤痕面积、左心室血流动力学指标、心肌病理指标及凋亡基因水平的影响。结果:心肌梗死后连续12周的DHI治疗可降低心脏和湿肺与体质量的比值、左室舒张末期压力、心肌细胞直径和胶原容积分数(P<0.05),升高左心室内压最大上升速率(P<0.05),但对凋亡基因的异常表达和心室前壁出现梗死疤痕无明显作用(P>0.05)。结论:丹红注射液可有效逆转CAL诱导的心肌梗死大鼠的心功能恶化并改善除凋亡外的心室重构。

OBJECtIVE To explore the improving effect of Danhong injection（DHI）on the cardiac function and left ventricu- lar remodeling in myocardial infarction rats. METHODS Coronary artery ligation （CAL） was used to induce an in vivo model of myocardial infarction （MI）. The experiment observed the influences of DHI on the anatomy indicators of heart and lung, ven tricular scar area, left ventricular hemodynamics, myocardial pathological indicators and the levels of apoptotic genes. RESULTS 12 consecutive weeks＂ treatment of DHI after myocardial infarction could reduce the ratio of HW/BW and WLW/ BW, left ventricular end-diastolic pressure, the diameter of cardiomyocyte and collagen volume fraction （P（0. 05）, and increase the maximum rate of change of left ventricular pressure（P^0. 05） ,while caused no changes on the ventricular scar area and the apoptosis. CONCLUSION Danhong injection can attenuate the deterioration of cardiac function and ventricular remodeling （ex- cept the apoptosis） in the myocardial infarction rats.