切应力对血管内皮细胞迁移的影响及其相关作用机制

The impact and modulation mechanism of normal shear stress on migration of endotheial cell

血管内皮细胞(endothelial cell,EC)迁移对于维持血管功能和结构的稳定具有重要作用。血液在血管中流动,从而使位于血管内层EC可以感受到切应力的作用。大量研究表明EC迁移受生物、化学和物理等多种体内外因素的调控,而切应力作为力学因素对EC的迁移具有重要调控作用。对切应力如何影响EC迁移及其作用机制进行综述。

Vascular endothelial cells （ECs） are constantly exposed to blood flow-induced shear stress, which has important impact on migration of ECs. And the station of ECs migration are essential to keep the vascular homeostasis. Numerous studies showed that migration of EC regulated by a variety of in vitro and in Vivo factors such as biological, chemical and physical. The impact of shear stress as a mechanical factor on ECs migration is important. This paper reviewed the impact of shear stress on ECs migration and the related modulation mechanism.