阿尔兹海默病中tau蛋白磷酸化调节

The regulation of phosphorylation of tau protein in Alzheimer’s disease

细胞内高度磷酸化tau蛋白形成的神经纤维缠结是阿尔兹海默病的主要病理特征之一。过度磷酸化的tau蛋白将引起细胞内微管的紊乱,从而造成神经元突触连接的丢失。Tau蛋白的磷酸化受到多种因素的影响,这些因素的失常将会导致tau蛋白的异常磷酸化。Tau蛋白的基本功能和结构、翻译后的主要修饰以及蛋白激酶和磷酸酯酶的调节,在阿尔兹海默病理以及预防治疗中发挥重要作用。

The intracellular neurofibrillary tangle leaded to by the hyperphosphorylated tau protein is one of the major pathological characters of the Alzheimer＇s disease （AD）. The hyperphosphorylated tau protein will make the microtube instable. Finally, the synapse between the neurons will be lost. There are many factors regulate the phosphorylation of tau protein, and the dysfunction of these factors may lead to the abnormal phosphorylation oftau protein. The basic structure and function oftau protein, the post-translational modifcation of tau protein as well as the function of the kinase and the phosphatase during phosphorylation regulation, play key roles on pathology, prevention and treatment of AD.