基于趋化因子受体CCR5阻断HIV-1感染的方法

Methods for blocking HIV-1 infection based on chemokine receptor 5

获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)主要是由HIV-1感染人体免疫细胞所造成,而介导HIV-1病毒进入机体细胞的主要辅助受体为趋化因子受体CCR5[chemokine(C-C motif)receptor 5],目前以CCR5为研究靶点阻断HIV-1感染的方法在医学和生物学领域备受关注,主要包括CCR5拮抗剂、RNA干扰(RNA interference,RNAi)、锌指核酸酶(zinc-finger nuclease,ZFN)和转录激活因子样效应物核酸酶(transcription activator-like effectors nuclease,TALEN)技术。趋化因子受体CCR5阻断HIV-1感染方法的相关研究进展有必要进行综述。

Acquired immunodeficiency syndrome is mainly caused by HIV-1 infection of the human immune cell. The entry of HIV-1 into target cells is mediated by a major coreceptor, CCR5. Currently, a lot of interest has been focused on the methods for blocking HIV-1 infection using CCR5 as a target in medical and biological research. These methods include CCR5 antagonists, small interfering RNA, and ZFNs （zinc finger nucleases） and TALENs （transcription activator-like effectors nucleases） techniques. It is necessary to review the progress on the methods for blocking HIV-1 infection based on chemokine receptor 5.