RIP140在各种组织中的作用

Roles of RIP140 in various tissues

受体相互作用蛋白140(receptor-interacting protein 140,RIP140)作为一种转录辅抑制因子,参与机体代谢调节。RIP140与核受体结合后能够负向调节脂肪、肌肉、心肌以及肝脏等多种组织中靶基因的转录。对其进行靶向沉默可上调多种组织中相关基因的表达,影响糖酵解、甘油三酯代谢、三羧酸循环、脂肪酸β氧化、炎症因子表达以及机体时钟变化等多种代谢过程,因此RIP140有望成为治疗代谢综合征的候选靶点。

Abstract： As a transcription auxiliary inhibitor, receptor-interacting protein 140 （RIP140） is involved in the regulation of metabolism in human body. Once combined with nuclear receptor, RIP140 can negatively regulate the transcription of target genes within a variety of metabolic organizations include the adipose tissue, muscle tissue, cardiac muscle and liver. When silenced, on the contrary, RIP140 will have an influence on glycolysis, triglyceride metabolism, the tricarboxylic acid cycle, fatty acid 13 oxidation, inflammatory factor expression, the body clock changes, etc. Therefore RIP 140 promises to be a candidate target site for the treatment of metabolic syndrome.