医院感染患者血粘附分子的变化意义

Expression of adhesive molecules in tissues and peripheral lymphocytes of patients with nosocomial infection

目的研究粘附分子在医院感染患者发病过程中的变化意义。方法用流式细胞术测定６４例医院感染患者血粘附分子ＣＤ４４， ＣＤ５４，ＣＤ６２Ｐ的变化，并与２０例正常人比较。结果医院感染患者血粘附分子ＣＤ４４（ ２１．２％９．１％），ＣＤ５４（５．４％±２．７％），ＣＤ６２Ｐ（１８．９％±７．６％）较正常人（８．６％ ±４．４％，２．０％ ±０．９３％，６．３％±３．５％）明显升高（Ｐ＜０．０１）；轻症医院感染患者上述指标（１５．２％ ±５．９％，４．０％±２．１％，１３．８％ ±５．６％）较重症医院感染患者（２７．２％± ８．１％，７．２％± ３．８％，２６．３％± ５．２％）显著降低（Ｐ＜０．０５），但仍高于正常人（Ｐ＜０．０５）。结论粘附分子升高在医院感染的发病机制中起重要作用，对判断或监测病情有一定意义。

OBJECTIVE To Study the expression of adhesive molecules in tissues and peripheral lymphocytes of patients with nosocomial infection (NI). METHODS CD44, CD54 and CD62P were assessed by using flow cytometry in 64 NI and 20 healthy volunteers. RESULTS CD44(21. 2 % ± 9. 1 % ), CD54(5. 4% ± 2. 7% ) and CD62P(18. 9% ± 7. 6% ) in blood were increased significantly in NI patients as compared with normal controls (8. 6% ± 4. 4%, 2. 0% ± 0. 93%, 6. 3% ± 3. 5%, P<0. 01). All these indexes were lower in mild patients (15. 2% ± 5. 9%, 4. 0% ± 2. 1 %, 13. 8% ± 5. 6% ) than those in severe ones (27.2 ± 8. 1%, 7.2% ± 3. 8%, 26. 3% ± 5.2%, P<0.05), which were still higher than that of norml controls (P<0.05). CONCLUSIONS Increased adhesive molecules are features of NI and may contribute to the pathogenesis of mucosal inflamma- tion.