含肟酯类姜黄素衍生物的合成及其抑菌活性研究

Synthesis and antifungal activities of oxime-esters of curcumin derivatives

将肟酯引入单羰基姜黄素衍生物1,5-二取代芳基-1,4-戊二烯-3-酮化合物中,通过醚化、肟化、酰化,最后酯化合成11个不对称1,5-二取代-1,4-戊二烯-3-酮肟酯类姜黄素衍生物,其结构经IR、1HNMR、13CNMR和元素分析确证。初步生物活性测试结果表明,部分化合物具有一定的抑菌活性。

Curcumin was modified by active functional group oxime ester with biologically active factor splicing of 1,5-diphenyl-1,4-pentadien-3-one compound. Eleven novel com-pounds were synthesized via etherification, oximic reaction and esterify reaction. The structure was identified by IR, 1HNMR,13 CNMR and element analysis. The preliminary bioassay indicated that some of the compounds exhibited good antifungal activity against Fusarium graminearum, Fusarium oxysporum and Cytospora mandshurica.