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2α-和4α-唑取代-5α-雄甾-3,17-二酮的绿色合成 被引量：1

Green method for synthesis of 2α and 4α-azole-substituted-5α-androstan-3,17-dione
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摘要 表雄酮经Jones氧化、溴化得2α-溴-5α-雄甾-3,17-二酮,后者与系列唑在无溶剂熔融条件下反应得标题化合物。与溶剂法比较,该法操作简便、反应时间短、收率高,且绿色环保。 2α-Bromine-5a-androstan-3,17-dione was synthe-sized from epiandrosteronevia Jones oxidation and bromina- tion. And then the bromide reacted with azoles under solvent- free conditions to give 2a-azole-substituted-5a-androstan- 3,17- dione and 4a-azole-substituted-5a-androstan-3, 17-di- one. The method is convenient and quick with high yield and environmental friendliness.
作者 柯贤炳 潘腾 吴杰 杨明利
机构地区 武汉生物工程学院制药工程系
出处 《化学试剂》 CAS CSCD 北大核心 2013年第3期271-273,共3页 Chemical Reagents
基金 国家自然科学基金资助项目(21102109) 湖北省自然科学基金资助项目(2010CDB06501) 武汉市青年科技晨光计划资助项目(201271031390) 湖北省教育厅资助项目(B20104606) 武汉市教育局资助项目(2009K103)
关键词 2α-溴-5α-雄甾-3 17-二酮 无溶剂反应 绿色合成 2α-bromine-Sa-androstan-3, 17-dione solvent- free reaction green synthesis
分类号 O629.2 [理学—有机化学]
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参考文献13

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二级参考文献8

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化学试剂
2013年 第3期

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