幽门螺杆菌感染与寻常型银屑病的相关性研究

Correlation between Helicobacter pyloriinfections and psoriasis vulgaris

目的探讨幽门螺杆菌(Hp)感染与寻常型银屑病的相关性。方法选取86例寻常型银屑病患者作为研究对象,随机分为A组及B组各43例,A组患者给与抗幽门螺杆菌三联疗法,并且外用维甲酸软膏进行治疗;B组患者单纯给与维甲酸软膏外用治疗;同时根据年龄、性别相匹配选取同期门诊正常体检者60例作为对照组。结果寻常型银屑病组Hp总感染率为52.33%,其中A组感染率48.84%,B组感染率55.81%,对照组Hp感染率为28.33%,寻常型银屑病组与对照组Hp感染率之间比较差异有统计学意义(χ2=8.33,P<0.05);治疗后寻常型银屑病组Hp感染转阴率91.11%,其中A组转阴率100.00%,B组转阴率70.83%,两组转阴率比较差异有统计学意义(χ2=85.20,P<0.05);PASI评分A组治疗前后分别为(15.51±8.46)分、(4.37±2.28)分,B组治疗前后分别为(15.72±8.02)分、(7.33±3.19)分,VAS评分A组治疗前后分别为(5.11±2.49)分、(2.15±1.38)分,B组治疗前后分别为(5.35±2.04)分、(3.24±1.82)分,A、B组PASI及VAS评分治疗后与治疗前比较差异有统计学意义(P<0.05),A、B组治疗后PASI及VAS评分比较差异有统计学意义(P<0.05);A组治疗总有效率为69.77%,B组治疗总有效率为30.23%,两组间比较差异有统计学意义(P<0.05)。结论 Hp感染与寻常型银屑病具有密切相关性,对异常型银屑病有Hp感染阳性患者应该考虑同时进行抗Hp治疗,有助于提高异常型银屑病的治疗疗效。

OBJECTIVE To study the relationship between the Helicobacter pylori（Hp） infections and the psoriasis vulgaris.METHODS A total of 86 patients with psoriasis vulgaris were selected as the study objects and were divided into the group A and group B with 43 cases in each.The group A was given the triple therapy for HP combined with the topical tretinoin ointment for the treatment,the group B was treated with the retinoic acid ointment only.At the same time,totally 60 normal people taking the physical examination who were matched with the age and gender were selected as the control group.RESULTS The total prevalence rate of the Hp infections was 52.33% in the psoriasis vulgaris group,the infection rate was 48.84% in the group A,55.81% in the group B.The prevalence rate of Hp infections was 28.33% in the control group,the difference in the prevalence rate of Hp infections between the psoriasis vulgaris group and the control group was statistically significant（χ2=8.33,P0.05）.After the treatment,the rate of the negative Hp infections was 91.11% in the psoriasis vulgaris group,the negative rate was 100.00% in the group A and 70.83% in the group B,the difference in the negative rate between the two groups was statistically significant（χ2=85.20,P0.05）.The PASI scores of the group A before and after the treatment were（15.51±8.46） points and（4.37±2.28） points,respectively,and the PASI scores of the group B were（15.72±8.02） points and（7.33±3.19）points.The VAS scores of the group A before and after the treatment were（5.11±2.49） points and（2.15±1.38） points,respectively,and the VAS scores of the group B before and after the treatment were（5.35±2.04） points and（3.24±1.82） points,respectively.The differences in the PASI score and VAS score between the group A and the group B before the treatment were statistically significant（P0.05）,the differences in the PASI score and VAS score between the group A and the group B after the treatment were statistically significant（P0.05）.The total effective rate of the treatment was 69.77% in the group A,30.23% in the group B,and the difference was statistically significant（P0.05）.CONCLUSION Hp infection is closely correlated with the psoriasis vulgaris,the anti-Hp therapy should be taken for the psoriasis vulgaris patients with the Hp infections.