头孢呋辛在骨科感染预防中的效果研究

Efficacy of cefuroxime in prevention of infections in orthopedics department

目的研究头孢呋辛在骨科感染预防中的效果,为预防和降低骨科感染提供参考。方法将医院2010年1月-2011年12月192例骨科手术患者随机分为两组,观察组96例患者,于术前给予头孢呋辛1.25g,术后继续用药1～2d;对照组96例患者,术前给予氨苄西林2g,术后继续用药1～2d,观察两组患者术后感染发生率、切口愈合情况及平均切口愈合时间。结果观察组共发生医院感染2例,分别为骨髓炎、蜂窝组织炎各1例,感染率为2.08%,对照组共发生感染11例,分别为切口感染3例,开放骨折术后感染及骨髓炎各2例,蜂窝组织炎4例,感染率为11.46%,对照组感染率明显高于观察组,两组比较差异有统计学意义(P<0.05);观察组平均切口愈合时间为(12.5±3.5)d,对照组平均切口愈合时间(16.5±5.5)d,观察组切口愈合状况:优72例,良22例,优良率97.92%,对照组优63例,良17例,优良率83.33%,两组比较差异有统计学意义(P<0.05)。结论头孢呋辛在骨科感染预防中效果显著,大大降低了感染发生率,缩短切口愈合时间及愈合质量。

OBJECTIVE To study the efficacy of cefuroxime in the prevention of infections in orthopedics department so as to provide basis for the prevention of orthopedic infections.METHODS A total of 192 patients undergoing orthopedic surgery from Jan 2010 to Dec 2011 were chosen as the study objects.They were randomly divided into two groups,the observation group of 96 patients was taken with preoperative administration of 1.25g of cefuroxime,and continued the medication for 1-2 days after the surgery.The control group of 96 patients was given with 2g of ampicillin,the patients continued to use for 1-2 days after the surgery.The incidence of infections,wound healing,and the average wound healing time of the two groups of patients were observed.RESULTS There were totally 2 cases with nosocomial infections in the observation group,1 case of osteomyelitis and 1 case of cellulite,the infection rate was 2.08%.There were 11 cases of infections in the control group,3 cases of incisional infections,2 cases of open fracture with postoperative infection,2 cases of osteomyelitis,and 4 cases of cellulites,the infection rate was 11.46%,the infection rate of the control group was significantly higher than that of the observation group,the difference was statistically significant（P0.05）.The mean wound healing time was（12.5±3.5） days in the observation group,（16.5±5.5） days in the control group.There were 72 cases of excellent incision healing and 22 cases of good incision healing with the good rate of 97.92% in the observation group,and there were 63 cases of excellent incision healing and 17 cases of good incision healing with the good rate of 83.33% in the control group,the difference was statistically significant（P0.05）.CONCLUSION Cefuroxime has a remarkable effect on the prevention of infections in orthopedics department,significantly reducing the incidence of infection,shortening the wound healing time as well as improving the quality of healing.