血必净注射液对肾移植术后肺部感染治疗的临床观察

Clinical observation on efficacy of xuebijing injection in treatmen t of pulmonary infections after renal transplantation

目的探讨血必净注射液对肾移植术后肺部感染患者治疗的效果。方法对39例行肾移植术并发肺部感染的患者在原治疗基础上采用血必净注射液静脉滴注,同时对患者的肾功能和生命体征进行监测,对患者血常规、尿常规、X线胸片和痰涂片进行复查。结果 39例患者经血必净治疗后痊愈33例,痊愈率84.6%,临床有效率97.4%;治疗后白细胞总数为(7.3±1.7)×109/L,明显低于治疗前的(13.7±2.9)×109/L,差异有统计学意义(t=22.27,P<0.05),氧分压指标治疗前和治疗后分别为(38.2±3.3)mm Hg和(83.1±5.4)mm Hg,差异有统计学意义(t=-63.75,P<0.05)。结论血必净中药注射液可以改善患者的微循环,并可减少炎症相关因子的释放,调节免疫功能,对感染肺组织具有良好的保护和修复功效。

OBJECTIVE To observe the effect of xuebijing injection on treatment of pulmonary infections after renal transplantation.METHODS Totally 39 patients with pulmonary infections after renal transplantation were received xuebijing injection.The renal function and vital signs of the patients were monitored,and the blood routine,urine routine,chest x-ray and sputum smear were reviewed.RESULTS The analysis of 39 cases showed that 33 of the 39 patients in the treatment group were cured,the rate of cure was 84.6%,and the total effective rate was 97.4%.After the treatment the leukocyte count was（7.3±1.7）×109/L,significant lower than（13.7±2.9）×109/L before the treatment（t=22.27,P0.05）.The oxygen partial pressure was（38.2±3.3） mmHg before the treatment and（83.1±5.4） mmHg after the treatment,the difference was statistically significant（t=-63.75,P0.05）.CONCLUSION Xuebijing injection is effective to improve the microcirculation,to reduce the release of inflammatory factors,and to regulate the immune function.It has a good efficacy in the conservation and restoration for infected lung tissue.