泌尿外科泌尿系感染大肠埃希菌耐药性临床调查分析

Investigation and analysis of drug resistance of Escherichia coli causing urinary tract infections in urology department

目的了解医院泌尿外科泌尿道感染的主要病原菌及其耐药性,以指导临床合理用药。方法回顾性调查2011年1-12月所有门诊与住院泌尿外科泌尿道感染病原学检测患者,对调查结果进行统计分析。结果 2011年1-12月中段尿标本共培养分离109株病原菌,以大肠埃希菌为主,62株占56.9%;62株大肠埃希菌中产ESBLs菌株为24株占38.7%;非产ESBLs菌株为38株占61.3%;产与非产ESBLs大肠埃希菌对氨苄西林、庆大霉素、左氧氟沙星、磺胺甲噁唑/甲氧苄啶、妥布霉素、环丙沙星的耐药率均≥50.0%。结论根据泌尿系感染的病原菌分布及耐药性,有针对性地选择用药,规范抗菌药物合理使用,降低泌尿道感染的发生。

OBJECTIVE To observe the drug resistance of the major pathogens causing urinary tract infections in urology department so as to guide the reasonable clinical medication.METHODS A retrospective survey was conducted for the etiology of the patients with urinary tract infections who enrolled the outpatient department and the urology department from Jan to Dec 2011,and the statistical analysis of the results was performed.RESULTS A total of 109 strains of pathogens were isolated from the midstream urine from Jan to Dec 2011,Escherichia coli was the predominant species of pathogens,accounting for 56.9%（62 strains）,there were 24（38.7%） strains of ESBLs-producing E.coli in the 62 strains of E.coli.There were 38（61.3%） strains of non-ESBLs-producing strains.The drug resistance rates of the ESBLs-producing and non-ESBLs-producing strains were all more than 50.0% resistant to ampicillin,gentamicin,levofloxacin,sulfamethoxazole,tobramycin,and ciprofloxacin.CONCLUSION The antibiotics should be used reasonably in accordance with the distribution and drug resistance of pathogens causing urinary tract infections,and the reasonable use of antibiotics can reduce the incidence of urinary tract infections.