肥大细胞在炎症性肠病发病中的作用机制

Role of mast cells in the pathogenesis of inflammatory bowel disease

炎症性肠病(inflammatory bowl disease,IBD)是一组反复发作的慢性炎症性肠道疾病,其发病机制并不十分清楚.越来越多的证据表明肥大细胞参与该病的发病.研究发现在IBD患者肠道黏膜中肥大细胞的数量增多了.肥大细胞被各种物质激活释放多种促炎症性细胞因子、化学物质及生物活性介质等在IBD的发生与发展中起重要作用.因此,了解肥大细胞释放的细胞因子和化学介质在IBD中的关键作用有望为治疗这种疾病开拓新的方法.

Inflammatory bowel disease （IBD） is a group of recurrent chronic intestinal inflammatory diseas- es with incompletely understood pathogenesis. Increasing evidence has shown that mast cells are markedly increased in inflamed mucosa of IBD patients and involved in the pathogenesis of IBD. Upon activation mast cells release multiple proinflammatory cytokines, chemokines and mediators that play an important role in the oc- currence and development of IBD. Understand- ing the role of mast cell-derived mediators and cytokines in IBD can provide new avenues for the development of new approaches to the treat-ment of this disease.