血管内皮细胞与炎症性肠病发生发展的关系

Effect of vascular endothelial cells on the pathogenesis of inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一组以肠道慢性炎症为主要表现的慢性复发性肠道自身免疫性疾病,包括克罗恩病(Crohn's disease,CD)和溃疡性结肠炎(ulcerative colitis,UC).在IBD的发病过程中,引起肠道炎症持续存在的重要原因和特征是黏膜组织中的炎细胞集聚和释放各种炎症因子,其中各种免疫细胞及肠微血管内皮细胞的功能变化对黏膜免疫和胃肠道生理改变发挥了十分重要的作用.这些改变中微血管内皮细胞的结构和功能改变能影响免疫细胞的迁移、组织的血供及内环境的稳定.新生血管通过血管内皮细胞调节炎症性细胞的招募、炎症介质和维持炎症反应进而引起组织损伤.

Inflammatory bowel disease （IBD）, including Crohn＇s disease （CD） and ulcerative colitis （UC）, are a group of chronic recurrent intestinal auto- immune diseases characterized by chronic intes- tinal inflammation. The important characteristics of persistent intestinal inflammation in IBD are the aggregation of inflammatory cells and the release of inflammatory factors in the intestinal mucosa. Functional alternations of immune cells and intestinal microvascular endothelial ceils play an important role in the mucosal immunity and intestinal function. Moreover, alternation of the structure and function of microvascular endo- thelial cells can regulate the migration of immune ceils, blood supply and homeostasis of intestinal tissue. Endothelial cells in newly formed vesselscan induce tissue injury by regulating the recruit- ment of blood cells and inflammatory mediators to maintain the inflammatory reaction.