溃疡性结肠炎动物模型的研究进展

Animal models of ulcerative colitis

溃疡性结肠炎(ulcerative colitis,UC)是一种主要局限于大肠黏膜和黏膜下层的慢性非特异性炎症性疾病,呈反复发作,临床表现主要为腹痛、腹泻、黏液脓血便.有资料统计,该病发病率和患病率在我国有明显增加趋势.但其确切病因和发病机制至今仍未阐明,治疗上也缺乏特异有效的药物.建立理想的,模拟人类溃疡性结肠炎的动物模型是非常重要的,因其对于UC病因、发病机制和新的治疗药物探讨有着重要意义.本文主要对近年来溃疡性结肠炎的几种动物模型进行述评.

Ulcerative colitis （UC） is a chronic, recurrent inflammatory disease of the colon, characterized clinically by bloody diarrhea and abdominal pain. UC has been a clinical challenge due to its increasing incidence and prevalence, unknown etiology and pathogenesis, and the lack of effec- tive treatment. Animal models have been widely used to investigate the pathogenesis of various diseases. So far, many animal models of UC have been developed, which play a crucial role in studying the pathogenesis of UC and finding new potential treatments. This article reviews the recent progress in the development of ani- mal models of UC.