胆红素吸附联合血浆置换治疗高胆红素血症42例

Therapeutic effect of plasma exchange combined with bilirubin absorption for hyperbilirubinemia:An analysis of 42 cases

目的:观察胆红素吸附(bilirubin absorption,BA)联合血浆置换(plasma exchange,PE)治疗高胆红素血症的临床疗效.方法:采用BA联合PE治疗高胆红素血症患者42例(共55例次),其中男28例,女14例;平均年龄52.14岁±8.52岁.结果:BA联合PE治疗组总有效率为95.24%,常规治疗组总有效率为76.66%.两组总有效率相比,有显著性差异(P<0.05);两组治疗前后肝功能改善比较有显著性差异,两组治疗后血清总胆红素、碱性磷酸酶改善比较有显著性差异(P<0.05).结论:BA联合PE治疗高胆红素血症是安全有效的治疗方法,并发症发生率低.

AIM： To analyze the therapeutic effect of plasma exchange （PE） combined with bilirubin absorp- tion （BA） in the treatment of hyperbilirubinemia. METHODS： Forty-two patients with hyperbili- rubinemia （55 events altogether） treated by PE combined with BA, including 28 males and 14 females, were enrolled. Their mean age was 52.14 years ＋ 8.52 years. RESULTS： The overall response rate was 95.24% for the combination treatment group and 76.66% for the normal treatment group. There was a significant difference in the overall response rate between the two groups （P 〈 0.05）. Both groupshad a significant improvement in liver function after treatment. The combination treatment was more effective in the improvement of TBil and alkaline phosphatase （ALP） levels （both P 〈 0.05）. CONCLUSION： PE combined with BA is safe and effective in the treatment of hyperbilirubinemia.