肝癌患者多次化疗栓塞术后肝纤维化指标变化

The Change Related to the Indicators of Hepatic neoplasm Patients After Repeated transcatheter arterial chemoembolization

目的：探讨多次肝动脉化疗栓塞术（ＴＡＣＥ）对肝纤维化进程的影响。材料与方法；选择２４例经三次以上ＴＡＣＥ治疗的肝癌患者，测定每次ＴＡＣＥ治疗前后透明质酸（ＨＡ）、人Ⅲ型前胶原（ｈｐｃⅢ）和Ⅳ型胶原（Ⅳ·Ｃ）的血清学水平，并进行比较研究。结果：ＴＡＣＥ治疗前后对比，三次肝纤维化指标均有不同程度的升高，以第三次ＴＡＣＥ术后升高最明显（Ｐ＜０．０１），三项肝纤维化指标中，以Ⅳ·Ｃ变化最显著，第一次ＴＡＣＥ术后即有统计学意义（Ｐ＜０．０５）。结论： ＴＡＣＥ治疗加重了肝纤维化进展，值得我们注意。

Purpose: To inverstigate whether transcatheter arterial chemoembolization (TACE) can aggravate the formation of cirrhosis of patients with hepatic neoplasm. Materials and Methods: We had detemined the contents of serum hyalnronate acid (HA), procollagen type - Ⅲ (hpcⅢ ), collagen type - Ⅳ (Ⅳ· C) of twenty four patients with hepatic neoplasm who had received more than three times of TACE. Results: Three fibrosis indicators of all patients rose more and less after curation of TACE. after third TACE. the indicators of fibrosis rose significantly (P < 0. 01 ). the most significantly one is collagen type Ⅳ, It could rise significantly (P< 0. 05 ) after the first curation of TACE. Conclusion: the repeated curation of TACE could promote the formation of hepatic cirrhosis. It should be paid attention to.