老年急性冠脉综合征患者脑钠肽水平对预后的评估分析

The assessment of the prognosis of elderly patients with acute coronary syndrome with brain natriuretic peptide levels

目的总结老年急性冠脉综合征(65≥岁)患者脑钠肽(BNP)水平对远近期预后的评估价值。方法选择不稳定型心绞痛(UAP)患者50例、急性ST段抬高型心肌梗死(STEMI)患者21例,急性非ST段抬高心肌梗死(NSTEMI)患者29例,正常对照组20例。测定其入院时和出院时血浆BNP浓度,与正常对照组20例相比较,观察并随访住院期间和出院后24个月内不良心脏事件的发生率、病死率。结果不稳定型心绞痛(UAP)、急性ST段抬高型心肌梗死(STEMI)、急性非ST段抬高型心肌梗死(NSTEMI)的BNP分别为(780.51±89.52)ng/L,(8588.04±369.50)ng/L和(3430.86±270.25)ng/L,冠脉病变越重,BNP越高,说明BNP与心肌缺血之间是关联的。BNP≥550 ng/L的患者住院期间与出院后24个月内不良心脏事件、病死率均高于BNP<550 ng/L的患者。结论BNP可以准确地评估ACS患者的危险程度和近远期预后。

Objective：To summarize the assessing value of brain natriuretfc peptide （BNP） levels in the fax-term prognosis of acute coronary syndrome （ ≥ 65years） patients. Methods： We selected 50 patients with unstable angina pectoris （UAP） ,21 patients with acute ST -segment elevation myocardial infarction （STEMI）, 29 patients with acute non-ST-segment elevation myocardial infarction （NSTEMI） in, and normal control group of 20 patients. Measured plasma BNP levels at admission and discharge, the 20 patients in normal control group were used as eomparlson to observe and the incidence and the mortality of adverse cardiac events within 24 months during hospitalization and after discharge. Results： unstable angina pcctoris （UAP）, acute ST-segment elevation myocardial infarction （STEMI）, acute non-ST-segment elevation myocordial infarction （NSTEMI） BNP （780.51± 89.52） ng/L, （8588.04 ±369.50） ng/L, （3430.86 ± 270.25 ） ng/L, coronary lesions heavier, BNP higher the BNP and myocardial isehemia is associated. BNP ≥ 550 ng / L in patients during hospitalization and adverse cardiac events within 24 months after discharge mortality than BNP 〈 550ng / L in patients. Conclusion ： BNP can accurately assess the degree of risk and near-term prognosis of patients with ACS.