釉基质蛋白促进自体移植牙牙周愈合的实验研究

The study of enamel matrix proteins on periodontal healing after autotransplantation of incisors in Beagle dogs

目的:研究釉基质蛋白对比格犬恒切牙自体移植后牙周愈合的影响。方法:选取3只比格犬的24颗切牙拔出后在生理盐水纱布中保存30min,然后将对照组12颗切牙直接植入同颌对侧同名牙牙槽窝中,实验组12颗切牙牙根涂釉基质蛋白后也植入对侧牙槽窝中。8周后通过组织学观察牙根的纵切片。结果:两组表面性吸收和炎症性吸收无统计学差异,但实验组牙根替代性骨吸收明显减少。结论:釉基质蛋白可减少牙根的替代性吸收,促进自体移植牙的牙周愈合。

Objective： To evaluate the effect of enamel matrix proteins （EMPs） on periodontal healing after autotransplantation of permanent incisors in Beagle dogs. Methods： A total of 24 incisors of 3 Beagle dogs were selected for autotransplantation after 30 min covered with wet saline gauge; 12 incisors of the control group were implanted in the opposite corresponding positions of the same jaw; 12 incisors of the experimental group were coated with EMPs and then implanted in the same positions. After 8 weeks, the longitudinal section of the incisor roots was observed with histological evaluation. Results： there was no significant difference between the control group and experimental group in surface absorption and inflammatory absorption, but there was significant decrease in replacement resorption. Conclusion： Enamel matrix protein can decrease the re- placement resorption, and promote periodontal healing of autotransplanted teeth.