尿中氧化应激指标作为学生体检中测定指标的意义

Value of urine oxidative stress index as a biomarker in student health examination

目的探讨尿中氧化应激指标作为学生体检中测定指标的意义。方法通过对体重指数(BMI)30以上的肥胖大学生34人进行晨尿采集,测定尿钠、肌酐、氧化应激指标[(H2O2和硫代巴比妥酸反应产物(TBARS)],观察尿中氧化应激水平和摄盐量(通过晨尿钠和肌酐公式测算)及现有体检指标(肥胖、血压、血脂等)的关系。结果尿中TBARS排泄量和日食盐摄入量、肥胖、血压、血脂之间有统计学意义的相关性(P<0.05)。结论建议学生体检中增加尿中TBARS排泄量测定,可以为学生人群的具体生活方式的指导提供量化的数据依据,同时作为一个心血管疾病的危险因子可以加深学生对心血管等疾病危害性的量化认识。

[ Objective ] To explore the value of urine oxidative stress index as a biomarker in student health examination. [ Methods ] Through morning urine collection of 34 obesity college students with body mass index （BMI） over 30, the urinary sodi-um, creatinine, oxidative stress indices （H202 and thiobarbituric acid reactive substances （TBARS） were determined. [ Results] The urine TBARS level was significantly correlated with daily salt intake, obesity , blood pressure , blood lipids （ P 〈 0.05 ）. [ Conclusion ] It is recommended that the urine oxidative stress index （ urine TBARS excretion） as a biomarker in student health examination which can provide specific guidance in lifestyle of the student population with quantitative data basis, at the same time as a risk factor for cardiovascular disease can deepen students＇understanding of cardiovascular disease hazards as quantization marker.