人乳头状瘤病毒16型、18型、单纯疱疹病毒2型和巨细胞病毒感染与宫颈癌的关系

Relationship between infection of HPV16,HPV18,HSV-2,cytomegalovirus and cervical cancer

目的探讨人乳头状瘤病毒(HPV)-16、18型、单纯疱疹病毒2型(HSV-2)和巨细胞病毒(CMV)感染与宫颈癌的关系。方法对66例宫颈癌、58例宫颈上皮内瘤样变(CIN)、20例慢性宫颈炎患者宫颈活检组织用聚合酶链反应方法检测HPV-16、18型、HSV-2和CMV感染情况。结果 HPV-16、18型、HSV-2、CMV阳性率从宫颈癌组到慢性宫颈炎组均有递减趋势;HPV-16型病毒的阳性例数中宫颈癌组分别与CIN组比较、慢性宫颈炎组比较差异有统计学意义(c2=28.714,c2=55.907,P<0.05),CIN组与慢性宫颈炎组比较差异有统计学意义(c2=11.507,P<0.05);HPV-18、HSV-2和CMV病毒的阳性例数中,宫颈癌组分别与CIN组、CIN组与慢性宫颈炎组比较差异无统计学意义(c2=1.758,c2=0.000,c2=0.937,P>0.05);在宫颈癌组中单独或合并HPV-16、HPV-18、HSV-2、CMV的感染率明显高于非宫颈癌组。结论HPV在引起宫颈癌的作用是主要的,HSV-2、CMV合并感染可能会增加患病的危险性,可将性传播疾病患者作为宫颈癌风险人群进行防癌筛查,以提高早期诊断和早期治疗率。

Objective To explore relationship between human papilloma virus （HPV）-16, 18 type, herpes simplex virus type 2 （HSV-2）, cytomegalovirus （CMV） infection and cervical cancer. Methods Sixty-six cases with cervical cancer, in- cluding 58 cases with cervical intraepithelial neoplasia （C1N）, 20 cases with chronic cervicitis were detected for infection of HPV-16 and 18, HSV-2 and CMV by polymerase chain reaction, 58 cases with cervical intraepithelial neoplasia （CIN）, and 20 cases with chronic cervicitis. Results There was decrement tendency of positive rate of HPV-16 and 18 type, HSV-2 and CMV from cervical cancer group to chronic cervicitis group. The positive rate was of statistical significance in HPV16 among groups of cervical cancer, CIN （;（2=28.714, P〈0.05） and chronic cervicitis （;（2=55.907, P〈0.05）, and between groups of CIN and chronic cervicitis （;（2=11.507, P〈0.05）, and also in HPV-18, HSV-2 and CMV respectively among groups of cervi- cal cancer,.CIN （;（5=0.037, ;（5=4.336, ;（2=2.225, P〉0.05） and chronic cervicitis （;（2=2.474, Z~=1.758, ;（2=0.000, P〉0.05）, CIN groups and chronic cervicitis groups （~=1.758, ~=0.000, ~＇=0.937, P〉0.05）. In cervical cancer group, single or combined in- fection rates of HPV-16, HPV-18, HSV-2, CMV virus were significantly higher than those of non-cervical cancer group. Conclusions HPV plays predominant role in causing cervical cancer, while HSV-2, CMV infection may increase the risk of cervical cancer. Sexually transmitted disease can be considered as a cervical cancer risk for screening, in order to improve the rate of early diagnosis and treatment.