苦石莲的化学成分研究

Study on Chemical Constituents of Caesalpinia minax

目的:研究苦石莲的化学成分。方法:利用硅胶柱色谱、重结晶等技术对苦石莲进行分离、纯化,通过波谱数据对化合物进行结构解析。结果:从苦石莲中分离纯化得到16个化合物,分别鉴定为caffeine(1)、β-谷甾醇(2)、十八烷酸(3)、熊果酸(4)、齐墩果酸(5)、β-胡萝卜苷(6)、3,5,7-三羟基-4'-甲氧基二氢黄酮醇(7)、neocaesalpin L(8)、neocaesalpin L1(9)、neocaesalpin K(10)、minaxin C(11)、阿魏酸(12)、咖啡酸(13)、没食子酸(14)、12α-ethoxyl-1α,6α,7β-triacetoxy-5α,14β-dihydroxy-cass-13(15)-en-16,12-olide(15)、stigmasta-5,22(E)-dien-3-beta-ol(16)。结论:化合物5,6,7,12,13,16均首次从该植物中分离得到,化合物7首次从豆科植物中分离得到。

Objective： To study the liver protecting chemical constituents of Caesalpinia minax. Method： The compounds were isolated and purified by silica gel columns, and recrystallization, and the structures of these compounds were identified by MS and NMR. Result： A total of 16 kinds of compounds were obtained.They were identified as caffeine（1）, β-sitosterol（2）, octadecanoic acid（3）, ursolic acid（4）, oleanolic acid（5）, β-daucosterol（6）, 3, 5, 7-3-hydroxy-4＇-methoxy dihydroflavonol（7）, neocaesalpin L（8）, neocaesalpin L1（9）, neocaesalpin K（10）, minaxin C（11）, ferulic acid（12）, caffeic acid（13）, gallic acid（14）, 12α-ethoxyl-1α, 6α, 7β-triacetoxy-5α, 14β-dihydroxy-cass-13（15）-en-16, 12-olide （15） and stigmasta-5, 22（E）-dien-3-beta-ol（16）. Conclusions： Compound 5, 6, 7, 12, 13, 16 were isolated from C. minax for the first time, and compound 7 was first obtained from the Leguminosae.