冠脉通胶囊对犬心肌缺血的保护作用

Effect of Guanmaitong Capsule in Acute Myocardial Ischemia in Dogs

目的:观察冠脉通胶囊对Beagle犬心功能的影响。方法:取Beagle犬42只,随机分7组,每组6只,分别为假手术组、模型对照组、冠脉通胶囊低剂量组(0.20 g.kg-1)、中剂量组(0.40 g.kg-1)、高剂量组(0.80 g.kg-1),冠心丹参胶囊0.07g.kg-1组,硝酸异山梨酯0.8 mg.kg-1组。按1 mL.kg-1ig给药6 d,第7天,将犬麻醉,手术结扎Beagle犬左冠状动脉前降支,造成急性心肌缺血模型,十二指肠给药,测定犬血流动力学参数左室收缩压(LVSP)、左心室舒张末期压(LVEDP)、左室内压上升及下降最大速率(±dp/dtmax)、心输出量(CO),观察冠脉通胶囊对犬急性心肌缺血的保护作用。结果:与假手术组相比,模型对照组LVEDP明显升高(P<0.05,P<0.01),LVSP,±dp/dtmax及CO明显降低(P<0.05,P<0.01);给药90,120,180min,冠脉通胶囊3个剂量组有降低LVEDP(均P<0.05)的作用,有升高LVSP,±dp/dtmax,CO的作用(均P<0.05)。结论:冠脉通胶囊有改善急性心肌缺血犬心功能的作用。

Objective： To investigate the effect of Guanmaitong capsule （GMT） on hemodynamic in Beagle dogs. Method： Forty-two Beagle dogs were randomly divided into seven groups： the sham operated control group, model group, GMT groups（0.20, 0.40, 0.80 g·kg-1）, Guanxin Danshen capsules group（0.07g·kg-1）, isosorbide dinitrate tablets group （0.80×10-3g·kg-1）.The Beagle dogs were administered by ig for six days. At the seventh day, acute myocardial ischemic model dogs were established by ligating left anterior decending coronary artery（LAD）.Guanmaitong capsule was administered to the canine by duodenal enema. Some hemodynamic parameters were observed. Result： Compared with the sham operated control group, the model group of left ventricular end dilated pressure （LVEDP） was decreasing （P〈0.05, P〈0.01） and left ventricular systolic pressure（LVSP）. ±dp/dtmax and cardiac output（CO） was raising obviously （P〈0.05, P〈0.01）.At the points of 90, 120, 180 min, the low, medium and high dose of Guanmaitong capsule could decrease LVEDP （all P〈0.05）, but raise LVSP, ±dp/dtmax, CO（all P〈0.05） after ligation of LAD. Conclusion： It indicates Guanmaitong capsule can improve the hemodynamic conditions of myocardial ischemic dogs.