绝经期后女性同型半胱氨酸、高敏C反应蛋白水平与冠状动脉病变及传统危险因素的关系

Association of High-sensitivity C Reactive Protein,Homocysteine with Coronary Lesions and Traditional Cardiovascular Risk Factors in Postmenopausal Women

目的:观察绝经期后女性冠心病患者高敏C反应蛋白(hs-CRP)和同型半胱氨酸(Hcy)水平,并分析hs-CRP,Hcy与冠状动脉病变和其他传统危险因素的关系。方法:入选绝经期后女性冠心病患者150例(CHD组),同期选取同年龄段男性冠心病患者150例(男性CHD组)及冠状动脉造影阴性的女性146例(非CHD组)作为对照组,比较3组患者一般资料及hs-CRP,Hcy水平。评价绝经期后女性冠心病患者冠状动脉病变与hs-CRP,Hcy的关系,并进行hs-CRP,Hcy与血脂、血压等传统危险因素相关性分析。结果:绝经期后女性冠心病患者同男性相比患高血压、糖尿病者明显增多;吸烟者较少,肾小球滤过率下降,hs-CRP和Hcy水平增高(P<0.05)。绝经期后女性冠心病患者中三支病变者hs-CRP和Hcy水平较单支病变者显著增高(P<0.05);重度病变患者hs-CRP和Hcy水平较轻度病变者增高明显(P<0.05)。hs-CRP和Hcy呈正相关(r=0.472,P<0.001);Hcy与体重指数(BMI),收缩压,舒张压呈正相关;hs-CRP与BMI,收缩压呈正相关,与肾小球滤过率(GFR)呈负相关。结论:绝经期后女性冠心病患者hs-CRP及Hcy水平增高,两者呈现正相关,且与血压,肥胖具有相关性。

Objective： To study the contribution of high-sensitivity C reactive protein （hs-CRP） and homocysteine （Hcy） on coronary lesions and investigate the association of that with traditional cardiovascular risk factors in postmenopausal women. Method： This study involved 150 consecutive postmenopausal women （CHD female group） with coronary heart disease （CHD）, 150 consecutive men with CHD （male group） and 146 postmenopausal women with non-CHD （non-CHD female group）.All patients underwent coronary angiography.The levels of hs-CRP and Hcy were detected in three groups.The association of hs-CRP, Hcy with coronary lesions and traditional cardiovascular risk factors was analyzed. Result： There were significant difference traditional cardiovascular risk factors including hypertension, type 2 diabetes in CHD female group than male group, the levels of hs-CRP and Hcy higher in CHD female group, but smoking and glomerular filtration rate（GFR） lower in CHD female group.In postmenopausal women, increased number of compromised arteries and total Gensini scores for the lesions were associated with increased levels of hs-CRP and Hcy.Correlation analysis showed a significant correlation among hs-CRP and Hcy（r=0.472, P〈0.001）; Hcy and body mass index（BMI）, systolic blood pressure（SBP）, diastdic blood pressure（DBP）; hs-CRP and BMI, SBP in postmenopausal women. Conclusion： The levels of hs-CRP and Hcy significant increased in postmenopausal women, and associated with each other.There was significant correlation among two newly emerged cardiovascular risk factors and obesity, hypertension.