摘要
目的观察比较克霉唑与制霉菌素栓治疗妊娠期外阴阴道假丝酵母菌病的疗效以及安全性,为治疗妊娠期外阴阴道假丝酵母菌病提供临床参考。方法选取2008年6月-2012年3月患外阴阴道假丝酵母菌病的妊娠期妇女124例,随机分为观察组与对照组,每组62例;观察组给予克霉唑治疗,对照组给予制霉菌素栓治疗,观察比较两组患者治疗后的疗效和用药安全性。结果观察组患者治疗后VVC评分明显低于对照组(P<0.05);观察组的治愈率为59.68%,明显高于对照组的50.00%(P<0.05);观察组的无效率为1.61%,明显低于对照组的6.45%(P<0.05);观察组的总有效率为87.10%,明显高于对照组的79.03%(P<0.05)。结论克霉唑治疗妊娠期外阴阴道假丝酵母菌病的疗效优于制霉菌素栓,两种药物均安全性良好。
OBJECTIVE To observe and compare the efficacy and safety of clotrimazole and nystatin suppository in treatment of vulvovaginal candidiasis during pregnancy so as to provide basis for the treatment of vulvovaginal candidiasis during pregnancy. METHODS A total of 124 patients with pregnancy vulvovaginal eandidiasis, who enrolled the hospital from Jun 2008 to Mar, were selected and randomly divided into the observation group and the control group with 62 cases in each; the observation group was treated with clotrimazole, the control group with nystatin suppository. The efficacy and safety of medication of the two groups were observed. RESULTS The VVC score of the observation group was obviously higher than that of the control group (P〈0.05). The cure rate of the observation group was 59. 68%, significantly higher than 50% of the control group (P〈 0. 05). The inefficiency of the observation group was 1.61 %, significantly lower than 6.45 % of the control group (P〈0.05) ; the total effective rate of the observation group was 87. 10%, significantly higher than 79.03% of the control group (P〈 0. 05). CONCLUSION The efficacy of clotrimazole is superior to that of nystatin suppository in treatment of pregnancy vulvovaginal candidiasis, and the safety of both two drugs is good.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第6期1422-1424,共3页
Chinese Journal of Nosocomiology